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DEVELOPMENT AND VALIDATION OF A SENSITIVE LC-LINEAR ION TRAP METHOD FOR THE DETERMINATION OF TRACE DI-IODOTHYRONINES IN HUMAN BLOOD SERUM

机译：敏感LC线性离子捕集方法的开发与验证用于测定人血清中痕量碘噻吩的痕量二碘噻吩

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In addition to the thyroid hormones (TH) 3,5,3'-triiodothyronine (T3) and L-thyroxine (T4), thyroid hormone metabolites (THM) exert their own distinct biological actions [1]. By incorporating MRM/MS3 switched scanning and extract de-lipidation, we have modified and validated our tandem mass spectrometry method [2] for 3,5-diiodothyronine (3,5-T2) and 3,3'-diiodothyronine (3,3'-T2) in human blood serum, and applied it to measure T2 concentrations in healthy individuals.

机译：除了甲状腺激素（TH）3,5,3'-三碘甲酚（T3）和L-甲状腺素（T4）外，甲状腺激素代谢物（THM）施加自己的不同的生物学作用[1]。通过掺入MRM / MS3切换扫描和提取脱脂，我们已经改进并验证了我们的串联质谱法[2] 3,5-二碘罗酮（3,5-T2）和3,3'-二碘罗酮（3,3 '-T2）在人体血清中，并将其应用于测量健康个体中的T2浓度。

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《International Mass Spectrometry Conference》|2018年|p1-627|共2页
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Keith Richards; Josef Kohrle; Daniel Rathmann; Raymond Monk;
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正文语种
中图分类分析化学;
关键词
Thyroid hormone metabolites; serum; tandem mass spectrometry; MS3; validation;

机译：甲状腺激素代谢物;血清;串联质谱;MS3;验证;

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DEVELOPMENT AND VALIDATION OF A SENSITIVE LC-LINEAR ION TRAP METHOD FOR THE DETERMINATION OF TRACE DI-IODOTHYRONINES IN HUMAN BLOOD SERUM

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