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CHEMOMETRIC OPTIMIZATION OF UPLC-MS/MS ASSAY FOR CLINICAL DIAGNOSIS AND PHARMACOTHERAPY MONITORING OF PATIENTS WITH APRT DEFICIENCY

机译：UPLC-MS / MS测定的化学计量优化对于APRT缺乏患者的临床诊断和药物疗法监测

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Patients with APRT deficiency have excessive renal excretion of 2,8-dihydroxyadenine (DHA), causing chronic kidney disease. Treatment with allopurinol or febuxostat reduces DHA excretion and kidney stones formation. A chemometric approach was used for optimization of a UPLC-MS/MS assay for simultaneous quantification of DHA, adenine biomarkers and the pharmacological agents in human urine and plasma for clinical diagnosis and pharmacotherapy monitoring.

机译：缺乏症的患者具有2,8-二羟基腺嘌呤（DHA）的肾脏排泄过多，导致慢性肾病。含有Allopurinol或Febuxostat的治疗可降低DHA排泄和肾结石形成。用于优化化学计量方法用于优化UPLC-MS / MS测定，用于同时定量DHA，腺嘌呤生物标志物和人尿液中的药理学药物和血浆中的临床诊断和药物治疗监测。

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《International Mass Spectrometry Conference》|2018年|p1-627|共2页
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作者
Margret Thorsteinsdottir; Unnur Arna Thorsteinsdottir; Finnur Freyr Eiriksson; Hrafnhildur L. Runolfsdottir; Vidar O Edvardsson; Runolfur Palsson;
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正文语种
中图分类分析化学;
关键词
Clinical mass spectrometry; UPLC-MS/MS; Chemometrics; Design of experiments; APRT deficiency;

机译：临床质谱;UPLC-MS / MS;化学计量学;实验设计;APR缺乏;

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专利

1. Quantitative UPLC-MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase deficiency (vol 1036, pg 170, 2016) [J] . Thorsteinsdottir Margret, Thorsteinsdottir Unnur A., Eiriksson Finnur F., Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2018,第期

机译：尿2,8-二羟基腺嘌呤的定量UPLC-MS / MS测定用于诊断和管理腺嘌呤磷酰基转移酶缺乏（Vol 1036，PG 170,2016）
2. Quantitative UPLC-MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase deficiency [J] . Thorsteinsdottir Margret, Thorsteinsdottir Unnur A., Eiriksson Finnur F., Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2016,第Null期

机译：尿中2,8-二羟基腺嘌呤的定量UPLC-MS / MS分析用于腺嘌呤磷酸核糖基转移酶缺乏症的诊断和治疗
3. Dried-Blood-Spot Technique to Monitor Direct Oral Anticoagulants: Clinical Validation of a UPLC-MS/MS-Based Assay [J] . Foerster Kathrin I, Huppertz Andrea, Meid Andreas D., Analytical chemistry . 2018,第15期

机译：干血斑技术监测直接口服抗凝剂：UPLC-MS / MS的临床验证
4. CHEMOMETRIC OPTIMIZATION OF UPLC-MS/MS ASSAY FOR CLINICAL DIAGNOSIS AND PHARMACOTHERAPY MONITORING OF PATIENTS WITH APRT DEFICIENCY [C] . Margret Thorsteinsdottir, Unnur Arna Thorsteinsdottir, Finnur Freyr Eiriksson, International Mass Spectrometry Conference . 2018

机译：UPLC-MS / MS测定的化学计量优化对于APRT缺乏患者的临床诊断和药物疗法监测
5. Development and validation of UPLC/MS/MS methods for quantification of gangliosides in the clinical study of ganglioside GM3 synthase deficiency. [D] . Huang, Qianyang. 2016

机译：神经节苷脂GM3合酶缺乏症临床研究中用于定量神经节苷脂的UPLC / MS / MS方法的开发和验证。
6. Simultaneous Determination and Risk Assessment of Pyrrolizidine Alkaloids in Artemisia capillaris Thunb. by UPLC-MS/MS Together with Chemometrics [O] . Li-Hua Chen, Jun-Chi Wang, Qi-Lei Guo, 2019

机译：同时测定青蒿中吡咯烷核生物碱的含量和风险评估。通过UPLC-MS / MS与化学计量学一起
7. Quantitative UPLC-MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase deficiency. [O] . Thorsteinsdottir, Margret, Thorsteinsdottir, Unnur A, Eiriksson, Finnur F, 2016

机译：尿中2,8-二羟基腺嘌呤的定量UPLC-MS / MS分析用于诊断和处理腺嘌呤磷酸核糖基转移酶缺乏症。

CHEMOMETRIC OPTIMIZATION OF UPLC-MS/MS ASSAY FOR CLINICAL DIAGNOSIS AND PHARMACOTHERAPY MONITORING OF PATIENTS WITH APRT DEFICIENCY

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