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首页> 外文会议>International Mass Spectrometry Conference >A RAPID AND HIGHLY SENSITIVE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY METHOD FOR SIMULTANEOUS DETERMINATION OF MELOXICAM AND 5'-CARBOXYMELOXICAM IN HUMAN PLASMA AND ITS APPLICATION TO A PHARMACO
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A RAPID AND HIGHLY SENSITIVE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY METHOD FOR SIMULTANEOUS DETERMINATION OF MELOXICAM AND 5'-CARBOXYMELOXICAM IN HUMAN PLASMA AND ITS APPLICATION TO A PHARMACO

机译：一种快速敏感的液相色谱 - 串联质谱法，用于同时测定人血浆中美洛昔康和5'-羧脲酰昔粒醛的应用及其在药物中的应用

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Meloxicam belongs to oxicam class of nonsteroidal anti-inflammatory drugs (NSAIDs) and is widely used to treat pain or swelling caused by osteoarthritis or rheumatoid arthritis. After oral administration of meloxicam, it is absorbed with bioavailability of 89% and has long half-life (22-24 hour). Meloxicam is extensively metabolized to four inactive metabolites by cytochrome P450 (CYP) 2C9 with a minor contribution of CYP3A4. The primary metabolic pathway of meloxicam is oxidation and 5'-carboxymeloxicam has been known for the major metabolite of meloxicam. The aim of the study was to develop and validate a more rapid and sensitive analytical method for simultaneous determination of meloxicam and 5'-carboxymeloxicam based on LC-MS/MS system.
机译：Meloxicam属于Oxicam类非甾体抗炎药（NSAIDs），并且广泛用于治疗由骨关节炎或类风湿性关节炎引起的疼痛或肿胀。在口服泌罗菌施用后，它被生物利用度吸收89％，半衰期长（22-24小时）。通过细胞色素P450（CYP）2C9，Cytochrome P450（CYP）2C9广泛地代谢至四种活性代谢物，具有CYP3A4的少量贡献。 Meloxicam的主要代谢途径是氧化，并且已知为美洛昔康的主要代谢物，5'-羧脲氧基胺已知。该研究的目的是开发和验证一种更快速和敏感的分析方法，用于同时测定基于LC-MS / MS系统的美洛昔康和5'-羧脲酰昔康。

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