Determination of drugs and metabolites in plasma samples provides the basis for phamacokinetic studies. Liquid chromatography-tandem mass spectrometry (LC/MS/MS)is playing more and more important role in this field because of its high sensitivity, selectivity, robustness and short measuring time. Examples of bioanalytical methods are reviewed for macrolide antibiotics, deoxynucleoside anti-HIV (human immunodeficiency virus) agents, dihydropyridine antihypertensives, and sulphonylurea antidiabetics.
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