CHIMERIC MULTIFUNCTIONAL LIGANDS FOR THE TREATMENT OF PAIN

机译：用于治疗疼痛的嵌合多功能配体

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Cholecystokinin (CCK) is known to give an anti-opioid effect and as a result, causes an increase of pain by inhibiting the opioid response. Recent research has shown further that melanocortin (MC) receptors, mainly subtype MC-4R, produce an increase in response to pain stimuli. Based on this previous work, we are developing chimeric ligands which will be of benefit to therapeutic pain treatment with enhanced opioid efficacy by acting as agonists at opioid receptors and antagonists at both CCK and MC receptors .

机译：已知胆囊蛋白（CCK）得到抗阿片类药物，因此通过抑制阿片类药物反应导致疼痛的增加。最近的研究进一步显示了Melanocortin（MC）受体，主要是亚型MC-4R，产生对疼痛刺激的反应增加。基于此前一项工作，我们正在开发嵌合配体，其将有益于治疗疼痛治疗，其通过作为阿片类受体的激动剂和在CCK和MC受体的拮抗剂中作为激动剂而具有增强的阿片类药物。

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《the European Peptide Symposium》|2007年||共2页
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Yeon Sun Lee; Vinod Kulkarni; Shou wu Ma;
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1. Discovery of Novel Multifunctional Ligands with mu/delta Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain [J] . Giri Aswini Kumar, Apostol Christopher R., Wang Yue, Journal of Medicinal Chemistry . 2015,第21期

机译：发现具有mu /δ阿片类激动剂/神经激肽-1（NK1）拮抗剂活性的新型多功能配体，可用于治疗疼痛。
2. Chimeric antigen receptor-redirected T cells display multifunctional capacity and enhanced tumor-specific cytokine secretion upon secondary ligation of chimeric receptor [J] . HendersonM.A., YongC.S.M., DuongC.P.M., Immunotherapy . 2013,第6期

机译：嵌合抗原受体重定向的T细胞在嵌合受体的二次连接后显示出多功能能力并增强了肿瘤特异性细胞因子的分泌
3. Development of non-viral, ligand-dependent, EPHB4-specific chimeric antigen receptor T cells for treatment of rhabdomyosarcoma [J] . Hiroshi Kubo, Shigeki Yagyu, Kayoko Nakamura, Molecular Therapy - Oncolytics . 2021,第a期

机译：非病毒，配体依赖性的ephb4特异性嵌合抗原受体T细胞用于治疗横纹肌肉瘤
4. CHIMERIC MULTIFUNCTIONAL LIGANDS FOR THE TREATMENT OF PAIN [C] . Yeon Sun Lee, Vinod Kulkarni, Shou wu Ma the European Peptide Symposium . 2007

机译：用于治疗疼痛的嵌合多功能配体
5. The Design, Synthesis, and Pharmacological Evaluation of Bifunctional Mu-/Delta-Selective Opioid Receptor Ligands for the Treatment of Pain [D] . Nastase, Anthony F. 2018

机译：双官能Mu-/ Delta-Selectience ApiOID受体配体的设计，合成和药理学评估治疗疼痛
6. Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain [O] . Aswini Kumar Giri, Christopher R. Apostol, Yue Wang, -1

机译：发现具有μ/δ阿片激动剂/神经激肽-1（NK1）拮抗剂活性的新型多功能配体可用于治疗疼痛。
7. Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain [O] . Akdemir, A., Edink, E.S., Thompson, A.J., 2012

机译：通过计算机筛选嵌合的α7受体配体结合结构域的晶体结构，鉴定新型α7烟碱受体配体

CHIMERIC MULTIFUNCTIONAL LIGANDS FOR THE TREATMENT OF PAIN

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