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首页> 外文会议>International Conference on Multifunctional Materials and Structures >Study the restenosis after Percutaneous transluminal coronary angioplasty(PTCA) in the organ culture system
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Study the restenosis after Percutaneous transluminal coronary angioplasty(PTCA) in the organ culture system

机译：在器官培养系统中术后经皮冠状动脉血管成形术（PTCA）后的再狭窄研究

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Percutaneous transluminal coronary angioplasty(PTCA) has become increasingly important in the therapy of coronary artery disease. However, the high restenosis occurrence of 20%～30% in patients limits the applications of this method, but the pathogenesis of restenosis has not yet been fully understood. In this paper, static organ culture system was set up to study the process of restenosis formation after PTCA. The common carotid arteries of atherosclerotic rabbits after PTCA were cultured in the artery organ-culture system and maintained in culture for 7 days. After 1d, 2d, 3d, 4d, 5d, 6d and 7d, MTT-test showed that the activity of vessels in the organ culture system unchanged. Pathology and histological technic were applied to check the intimal morphology especially the endothelial denudation and intimal hyperplasia. The concentration of chemical cytokines NO releasing in the process of restenosis were measured. The results showed the method of static organ culture could be successfully applied to keep the activity of culture arteries and study the process of restenosis formation after PTCA. The endothelial denudation and inflammatory cytokines releasing had intimately relationship with the restenosis after PTCA.
机译：经皮腔冠状动脉血管成形术（PTCA）在冠状动脉疾病的治疗中越来越重要。然而，患者的高再狭窄发生20％〜30％限制了这种方法的应用，但尚未完全理解再狭窄的发病机制。本文，建立了静电器官培养系统，研究了PTCA后再狭窄形成过程。 PTCA后动脉粥样硬化兔的常见颈动脉在动脉器官培养系统中培养并维持在培养物7天。在1D，2D，3D，4D，5D，6D和7D之后，MTT测试显示，器官培养系统中的容器的活性不变。将病理学和组织学技术应用于检查内皮形态，特别是内皮剥落和内膜增生。测量化学细胞因子的浓度没有在再狭窄过程中释放。结果表明，静电器官培养方法可以成功地应用于保持培养动脉的活性，并研究PTCA后再狭窄形成过程。内皮剥落和炎症细胞因子释放与PTCA后的再狭窄密切相关。

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