• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Society for Free Radical Research International >Gene Expression Signatures of Environmental Chemical in Cancer and Developmental Disorders
【24h】

Gene Expression Signatures of Environmental Chemical in Cancer and Developmental Disorders

机译：癌症和发育障碍环境化学的基因表达特征

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The determination of gene expression signatures as a means to explore cellular responses to chemical exposures offers a new approach for predicting such responses and to investigate chemical agent-gene interactions. Here, we focus on genes responsive to oxidative stress in metal-induced toxicity in rats and humans, and non-metal-induced toxicity in embryonic stem cells. We apply a statistical clustering and a Bayesian network analysis technique, which is a probabilistic graphical model that represents a set of variable identities. We found that the gene expression signature of copper accumulation in the LEC rat liver was unique for this toxic agent. Next, we showed differential gene expression patterns following arsenic exposure in the human liver cell line HepG2 and in human cord blood. Finally, we showed that the gene expression signature of retinoic acid exposure in embryonic stem (ES) cells could be useful for to predicting neuronal disease.
机译：基因表达签名的测定作为探讨化学曝光的细胞反应的方法提供了一种预测这些反应的新方法，并研究化学试剂 - 基因相互作用。在这里，我们专注于响应于大鼠和人类的金属诱导的毒性氧化应激的基因，以及胚胎干细胞中的非金属诱导的毒性。我们应用统计聚类和贝叶斯网络分析技术，这是一种代表一组可变标识的概率图形模型。我们发现，LEC大鼠肝脏铜积累的基因表达特征对于这种有毒剂是独一无二的。接下来，我们在人肝细胞系HepG2和人脐带血中显示酰胺暴露后的差异基因表达模式。最后，我们表明胚胎茎（ES）细胞中视黄酸暴露的基因表达特征可用于预测神经元疾病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号