IDENTIFICATION OF THE TYROSINE KINASE RECEPTOR KIT AS A MOLECULAR TARGET IN NEOPLASTIC FELINE MAST CELLS

机译：鉴定酪氨酸激酶受体试剂盒作为肿瘤猫型肥大细胞的分子靶标

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Systemic mastocytosis (SM) in felines is a rare neoplasm defined by increased growth and accumulation of immature mast cells (MC) in various organ systems. In advanced SM, the prognosis is grave. In these patients, neoplastic MC usually show a poor response to conventional drug therapy. Recent data suggest that Kit-targeting drugs may interfere with growth of neoplastic MC in humans. In this study, we examined the effects of four Kit tyrosine kinase inhibitors (TKI), imatinib (STI571), midostaurin (PKC412), nilotinib (AMN107), and dasatinib (BMS354825), on growth of feline neoplastic MC.

机译：Felines中的全身乳细胞增长症（SM）是一种罕见的肿瘤，通过增加各种器官系统中未成熟肥大细胞（MC）的增长和积累而定义。在高级SM中，预后是坟墓。在这些患者中，肿瘤MC通常表现出对常规药物治疗的不良反应。最近的数据表明，试剂盒靶向药物可能会干扰人类肿瘤MC的生长。在这项研究中，我们研究了四个试剂蛋白激酶抑制剂（TKI），伊马替尼（STI571），中豚（PKC412），尼洛替尼（AMN107）和Dasatinib（BMS354825）的效果对猫肿瘤MC的生长。

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《Annual conference of the Veterinary Cancer Society》|2008年||共1页
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Emir Hadzijusufovic; Barbara Peter; Laura Rebuzzi; Christian Baumgartner; Karoline V Gleixner; Alexander Gruze; Michael Kneidinger; Winfried F Pickl; Michael Willmann; Peter Valent;
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1. Growth-inhibitory effects of four tyrosine kinase inhibitors on neoplastic feline mast cells exhibiting a Kit exon 8 ITD mutation [J] . Hadzijusufovic Emir, Peter Barbara, Rebuzzi Laura, Veterinary Immunology and Immunopathology . 2009,第2a4期

机译：四种酪氨酸激酶抑制剂对具有Kit外显子8 ITD突变的肿瘤猫肥大细胞的生长抑制作用
2. Kit receptor tyrosine kinase dysregulations in feline splenic mast cell tumours [J] . Veterinary and Comparative Oncology . 2017,第3期

机译：Kit受体酪氨酸激酶激酶在猫素脾脏肥大细胞瘤中的缺血剂
3. Prognostic significance of Kit receptor tyrosine kinase dysregulations in feline cutaneous mast cell tumors. [J] . Sabattini S., Frizzon M. G., Gentilini F., Veterinary Pathology . 2013,第5期

机译：Kit受体酪氨酸激酶失调在猫皮肤肥大细胞肿瘤中的预后意义。
4. IDENTIFICATION OF THE TYROSINE KINASE RECEPTOR KIT AS A MOLECULAR TARGET IN NEOPLASTIC FELINE MAST CELLS [C] . Emir Hadzijusufovic, Barbara Peter, Laura Rebuzzi, Annual conference of the Veterinary Cancer Society . 2008

机译：鉴定酪氨酸激酶受体试剂盒作为肿瘤猫型肥大细胞的分子靶标
5. Examining the role of redox biology in a population of neonatal cardiac precursor cells marked by the type III receptor tyrosine kinase c-kit. [D] . Nadworny, Alyson Spealman. 2012

机译：检查氧化还原生物学在以III型受体酪氨酸激酶c-kit标记的新生儿心脏前体细胞中的作用。
6. Growth-inhibitory effects of four tyrosine kinase inhibitors on neoplastic feline mast cells exhibiting a Kit exon 8 ITD mutation [O] . Emir Hadzijusufovic, Barbara Peter, Laura Rebuzzi, -1

机译：四种酪氨酸激酶抑制剂对表现出套件外显子8 ITD突变的肿瘤猫培养物细胞的生长抑制作用
7. Growth-inhibitory effects of four tyrosine kinase inhibitors on neoplastic feline mast cells exhibiting a Kit exon 8 ITD mutation [O] . Emir Hadzijusufovic, Barbara Peter, Laura Rebuzzi, 2009

机译：四种酪氨酸激酶抑制剂对表现出套件外显子8 ITD突变的肿瘤猫培养物细胞的生长抑制作用

IDENTIFICATION OF THE TYROSINE KINASE RECEPTOR KIT AS A MOLECULAR TARGET IN NEOPLASTIC FELINE MAST CELLS

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