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Fast Solid-Phase Peptide Synthesis of p-Amyloid (1-42) and the 68-mer Chemokine SDF-1α on the Symphony X~(TM) Multiplex Peptide Synthesizer

机译：基淀粉样蛋白（1-42）的快速固相肽合成 - 交响曲X〜（TM）多重肽合成器对68-MEL趋化因子SDF-1α

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Human p-amyloid (1-42) peptide (Figure 1) is a major component of the plaque deposits found in the brains of Alzheimer's disease (AD) patients [1]. Continued research into the pathology and potential therapeutics for AD has sustained demand for this peptide. Synthesis of the p-amyloid (1-42) peptide by conventional solid phase peptide synthesis has been reported to be difficult due to the high hydrophobicity of the C-terminal segment and on-resin aggregation [2].

机译：人对淀粉样（1-42）肽（图1）是在阿尔茨海默病（AD）患者的大脑中发现的斑块沉积物的主要成分[1]。持续研究了广告的病理学和潜在治疗方法对该肽的需求持续了需求。据报道，通过常规固相肽合成来合成常规固相肽合成的肽由于C-末端区段和树脂聚集的高疏水性而难以困难[2]。

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《American Peptide Symposium》|2013年||共2页
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James P. Cain; Christina A. Chantell; Michael A. Onaiyekan;
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1. Efficient infrared (IR) heating method for solid-phase peptide synthesis on the Tribute? and Symphony X? peptide synthesizers [J] . JAMES P. CAIN, MICHAEL A. ONAIYEKAN, CHRISTINA A. CHANTELL, PharmaChem . 2013,第11a12期

机译：在Tribute上进行固相肽合成的高效红外（IR）加热方法？和交响乐X？肽合成仪
2. Efficient infrared heating method for solid-phase peptide synthesis on the Tribute peptide synthesizer [J] . JAMES P. CAIN, MICHAEL A. ONAIYEKAN, CHRISTINA A. CHANTELL, PharmaChem . 2012,第5a6期

机译：Tribute肽合成仪上固相肽合成的高效红外加热方法
3. Fast Conventional Synthesis of Human B-Amyloid (1-42) on the Symphony and Prelude~(TM) [J] . German Fuentes, Christina Hood, Jae H. Park Advances in Experimental Medicine and Biology . 2008,第Null期

机译：在Symphony和Prelude〜（TM）上快速常规合成人B-淀粉样蛋白（1-42）
4. Fast Solid-Phase Peptide Synthesis of p-Amyloid (1-42) and the 68-mer Chemokine SDF-1α on the Symphony X~(TM) Multiplex Peptide Synthesizer [C] . James P. Cain, Christina A. Chantell, Michael A. Onaiyekan American Peptide Symposium . 2013

机译：基淀粉样蛋白（1-42）的快速固相肽合成 - 交响曲X〜（TM）多重肽合成器对68-MEL趋化因子SDF-1α
5. I. Selection, synthesis, and mechanisms studies of cell-penetrating peptides: New drug delivery systems. II. Biological lessons for the preparation of Abeta(1-42) and cyclic peptide probe for the detection of botulinum neurotoxin A. [D] . Kim, YoungSoo. 2006

机译：I.细胞穿透肽的选择，合成和机理研究：新药物递送系统。二。制备Abeta（1-42）和用于检测肉毒杆菌神经毒素A的环肽探针的生物学课程。
6. Design and validation of a frugal automated solid-phase peptide synthesizer [O] . Nathaniel E. Kallmyer, Nathan E. Rider, Nigel F. Reuel 2020

机译：节俭自动化固相肽合成器的设计和验证
7. Fast Solid-Phase Peptide Synthesis of β-Amyloid (1-42) and the 68-mer Chemokine SDF-1α on the Symphony XTM Multiplex Peptide Synthesizer [O] . James P. Cain, Christina A. Chantell, Michael A. Onaiyekan, 2013

机译：快速固相肽合成β-淀粉样蛋白（1-42）和Symphony XTM多重肽合成器对68-MEL趋化因子SDF-1α

Fast Solid-Phase Peptide Synthesis of p-Amyloid (1-42) and the 68-mer Chemokine SDF-1α on the Symphony X~(TM) Multiplex Peptide Synthesizer

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