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Antiproliferative Effect of Lamprey Gonadotropin-releasing Hormone III on Cancer Cells from Non-reproductive Organs

机译:羊斑促性腺激素释放激素III对非生殖器官癌细胞的抗增殖作用

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Receptors for gonadotropin-releasing hormone (GnRH) are expressed in many extra-pituitary tissues and their role and mechanism of action in gynecological tumors are well characterized. GnRH and its analogs utilize the G_(q/11) signaling pathway in the pituitary whereas, in ovarian, endometrial, and prostate cancer cells, the G_i pathway is activated.
机译:在许多垂体脑膜组织中表达了促性腺激素释放激素(GnRH)的受体,其作用和妇科肿瘤中作用的作用以及很好的表征。 GNRH及其类似物利用垂体中的G_(Q / 11)信号通路,而在卵巢,子宫内膜和前列腺癌细胞中,激活G_I途径。

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