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Comparing Antimicrobial and Membrane Permeabilizing Activity of Peptides Derived from Human Cationic Proteins

机译：比较人阳离子蛋白肽的抗微生物和膜透析活性

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The increasing occurrence of pathogenic bacteria that are resistant to commercially available antibiotics has led to a growing interest in the development of peptides as a novel class of antibacterial drugs. Since bacteria have evolved to present multiple resistances to a large number of existing antibiotics, a new class of compounds is more likely to minimize the rapid emergence of bacterial resistance. Nature has taught us that effector molecules of mammalian innate immunity can provide a first line of defense against a substantial array of pathogenic microorganisms. In particular, host-defense peptides are considered to be multifunctional effector molecules and represent novel sources for the development of therapeutic agents with which to overcome antimicrobial resistance. Today, several hundred host defense peptides have been isolated from natural sources and their functions characterized [reviewed in 1-3]. These peptides are important components of innate defenses, since they not only have the ability to kill bacteria, but are also able to modulate inflammatory responses. While many conventional antibiotics damage or kill bacteria over a period of days, most antimicrobial peptides affect the bacterial membrane and kill almost instantaneously, i.e., within minutes. Therefore, a permeabilizing peptide may be able to counteract mechanisms of antibiotic resistance relying on an efficient membrane permeability barrier and be of great value in a combination therapy against drug-resistant bacterial strains.
机译：耐药细菌的发生越来越多的致病细菌导致肽作为一种新型抗菌药物的发育而越来越感兴趣。由于细菌已经进化到大量现有抗生素的多种抗性，因此新类化合物更可能最小化细菌抗性的快速出现。大自然教导了我们哺乳动物的效应分子可以为一系列反对大量致病微生物提供第一线。特别地，宿主防毒肽被认为是多功能效应分子，并且代表用于克服抗微生物抗性的治疗剂的新源。如今，几百个宿主防御肽已从自然来源中分离出来，其功能特征在于[1-3]。这些肽是先天防御的重要组成部分，因为它们不仅具有杀死细菌的能力，而且还能够调节炎症反应。虽然许多常规的抗生素损伤或杀死细菌在一段时间内，但大多数抗微生物肽影响细菌膜，几乎瞬间杀死，即在几分钟内。因此，渗透肽可以能够抵消依赖于有效膜渗透屏障的抗生素抗性机制，并且在耐药细菌菌株的联合治疗中具有很大的价值。

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