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G protein-coupled receptor mediated sensing of TMA

机译：G蛋白偶联受体介导的TMA的感测

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A new approach for the detection of trimethylamine (TMA) using recombinant Xenopus laevis melanophores was developed. The cells were genetically modified to express the mouse trace amine-associated receptor 5 (mTAAR5), a G protein-coupled receptor from the olfactory epithelium, which conferred high sensitivity to TMA. A focused chemical screen allowed the discovery of additional, previously unknown stimuli of mTAAR5. The cell-based sensor demonstrated no sensitivity to trimethylamine Noxide (TMAO), making it suitable for a convenient evaluation of TMA levels in fish tissue extracts. The developed gas measurement platform was able to detect TMA from 1 to 100 ppm within thirty-five minutes.

机译：开发了一种使用重组Xenopus Laevis Melanophors检测三甲胺（TMA）的新方法。遗传修饰细胞以表达小鼠痕量胺相关的受体5（MTAAR5），来自嗅觉上皮的G蛋白偶联受体，其赋予TMA的高敏感性。聚焦化学筛网允许发现额外的，以前未知的MTAAR5刺激。基于细胞的传感器对三甲胺NONEDIDE（TMAO）表示不敏感，这适于方便地评估鱼类组织提取物中的TMA水平。发达的气体测量平台能够在三十五分钟内检测1至100 ppm的TMA。

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《Eurosensors Conference》|2009年||共4页
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作者
Anke Suska; Ana B. Ibanez; Pakorn Preechaburana; Ingemar Lundstrom; Anna Berghard;
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中图分类 TP212-53;
关键词
Cell-based sensor; Trace amine-associated receptor; TAAR5; Trimethylamine detection; Xenopus laevis melanophores;

机译：基于细胞的传感器;痕量胺相关受体;Taar5;三甲胺检测;Xenopus Laevis Melanophores;

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1. Selective regulation of G protein-coupled receptor-mediated signaling by G protein-coupled receptor kinase 2 in FRTL-5 cells: analysis of thyrotropin, alpha(1B)-adrenergic, and A(1) adenosine receptor-mediated responses. [J] . Iacovelli L, Franchetti R, Grisolia D, Molecular pharmacology. . 1999,第2期

机译：G蛋白偶联受体激酶2在FRTL-5细胞中的G蛋白偶联受体介导的信号的选择性调节：促甲状腺素，α（1B）-肾上腺素和A（1）腺苷受体介导的反应的分析。
2. The putative G protein-coupled receptor GrlD mediates extracellular polyphosphate sensing in Dictyostelium discoideum [J] . Suess Patrick M., Tang Yu, Gomer Richard H. Molecular biology of the cell . 2019,第9期

机译：推定的G蛋白偶联受体GRLD在Dictyostelium discoideum中介导细胞外多磷酸盐感应
3. G protein-coupled receptor mediated trimethylamine sensing [J] . Suska A, Ibanez AB, Lundstrom I, Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices . 2009,第4期

机译：G蛋白偶联受体介导的三甲胺感测
4. G protein-coupled receptor mediated sensing of TMA [C] . Anke Suska, Ana B. Ibanez, Pakorn Preechaburana, Eurosensors Conference . 2009

机译：G蛋白偶联受体介导的TMA的感测
5. Protein interactions mediating endocytic recycling of G protein-coupled receptors. [D] . Lauffer, Benjamin E.L. 2008

机译：蛋白质相互作用介导G蛋白偶联受体的内吞再循环。
6. G Protein-coupled Receptor Kinase 2–mediated Phosphorylation of Ezrin Is Required for G Protein-coupled Receptor–dependent Reorganization of the Actin Cytoskeleton [O] . Sarah H. Cant, Julie A. Pitcher 2005

机译：G蛋白偶联受体依赖的肌动蛋白细胞骨架重组需要G蛋白偶联受体激酶2介导的Ezrin磷酸化。
7. G protein-coupled receptor mediated sensing of TMA [O] . Suska, Anke, Belen Ibanez, Ana, Preechaburana, Pakorn, 2009

机译：G蛋白偶联受体介导的TMA感测

G protein-coupled receptor mediated sensing of TMA

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