首页> 外文会议>Annual Conference of the Veterinary Cancer Society >PROSPECTIVE TRIAL OF 5-AZACITIDINE IN DOGS WITH NATURALLY-OCCURRING INVASIVE URINARY BLADDER CANCER, AN EPIGENETIC APPROACH TO CANCER THERAPY.

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PROSPECTIVE TRIAL OF 5-AZACITIDINE IN DOGS WITH NATURALLY-OCCURRING INVASIVE URINARY BLADDER CANCER, AN EPIGENETIC APPROACH TO CANCER THERAPY.

机译：患有自然侵袭性膀胱癌的5-氮杂氨酸的前瞻性试验，癌症治疗的表观遗传方法。

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Epigenetic silencing of tumor suppressor genes by hypermethylation is common in human invasive urinary bladder cancer (transitional cell carcinoma, TCC). Demethylating agents, such as 5-azacitidine (5-aza), may provide novel treatment for TCC. Naturally-occurring canine TCC mimics human invasive TCC. Studies in dogs may provide key information about 5-aza (efficacy, toxicity, dosage) to help plan human clinical trials.

机译：通过高甲基化肿瘤抑制基因的表观遗传沉默在人类侵袭性尿膀胱癌（过渡细胞癌，TCC）中是常见的。去甲基化试剂如5-氮杂氨酸（5-AZA），可以为TCC提供新的处理。天然发生的犬TCC模仿人类侵袭性TCC。狗的研究可以提供约5-αza（疗效，毒性，剂量）的关键信息，以帮助计划人类临床试验。

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《Annual Conference of the Veterinary Cancer Society》|2009年||共1页
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Noah Hahn; Deborah Knapp; Michael Childress; Patty Bonney; David Jones; Corie Hartman-Frey; Royal Balch; Jane Stewart; Kenneth Nephew;
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1. Microsatellite Analysis of Voided-Urine Samples for Surveillance of Low-Grade Non-Muscle-Invasive Urothelial Carcinoma: Feasibility and Clinical Utility in a Prospective Multicenter Study (Cost-Effectiveness of Follow-Up of Urinary Bladder Cancer Trial (CEFUB)) [J] . Madelon N.M. van der Aa, Ellen C. Zwarihoff, Ewout W. Steyerberg, European urology . 2009,第3期

机译：尿液样本微卫星分析对低级别非肌肉侵袭性尿道上皮癌的监视：一项前瞻性多中心研究的可行性和临床实用性（膀胱膀胱癌试验随访成本（CEFUB））
2. Naturally Occurring Canine Invasive Urinary Bladder Cancer: A Complementary Animal Model to Improve the Success Rate in Human Clinical Trials of New Cancer Drugs [J] . Christopher M. Fulkerson, Deepika Dhawan, Timothy L. Ratliff International Journal of Genomics . 2017,第Pta1期

机译：天然存在的犬侵袭性尿膀胱癌：一种互补的动物模型，提高新癌症药物临床试验中的成功率
3. Pretreatment tumor prostaglandin E2 concentration and cyclooxygenase-2 expression are not associated with the response of canine naturally occurring invasive urinary bladder cancer to cyclooxygenase inhibitor therapy. [J] . Mutsaers AJ, Mohammed SI, DeNicola DB, Prostaglandins, Leukotrienes, and Essential Fatty Acids . 2005,第3期

机译：预处理肿瘤前列腺素E2浓度和环氧合酶2表达与犬自然发生的浸润性膀胱癌对环氧合酶抑制剂治疗的反应无关。
4. PROSPECTIVE TRIAL OF 5-AZACITIDINE IN DOGS WITH NATURALLY-OCCURRING INVASIVE URINARY BLADDER CANCER, AN EPIGENETIC APPROACH TO CANCER THERAPY. [C] . Noah Hahn, Deborah Knapp, Michael Childress, Annual Conference of the Veterinary Cancer Society . 2009

机译：患有自然侵袭性膀胱癌的5-氮杂氨酸的前瞻性试验，癌症治疗的表观遗传方法。
5. Cystoscopy and the development of invasive bladder cancer in patients presenting with superficial urinary bladder cancer. [D] . Amos, Charles E., Jr. 2003

机译：膀胱镜检查和浅表性膀胱癌患者的浸润性膀胱癌的发展。
6. Naturally-Occurring Invasive Urothelial Carcinoma in Dogs a Unique Model to Drive Advances in Managing Muscle Invasive Bladder Cancer in Humans [O] . Deborah W. Knapp, Deepika Dhawan, José A. Ramos-Vara, 2019

机译：狗的天然存在的侵袭性尿路上皮癌是一种驱动人类肌肉侵袭性膀胱癌的进步的独特模型
7. Naturally-Occurring Invasive Urothelial Carcinoma in Dogs, a Unique Model to Drive Advances in Managing Muscle Invasive Bladder Cancer in Humans [O] . Deborah W. Knapp, Deepika Dhawan, José A. Ramos-Vara, 2020

机译：狗的天然存在的侵袭性尿路上皮癌，是一种驱动人类肌肉侵袭性膀胱癌的进步的独特模型

PROSPECTIVE TRIAL OF 5-AZACITIDINE IN DOGS WITH NATURALLY-OCCURRING INVASIVE URINARY BLADDER CANCER, AN EPIGENETIC APPROACH TO CANCER THERAPY.

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