Simultaneous Determination of udenafil and its Active Metabolite, DA-8164, in Free Fraction Human Plasma by LC-ESI/MS/MS

机译：通过LC-ESI / MS / MS同时测定udenafil及其活性代谢物，DA-8164，自由级分子血浆

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

We established a new validated method for the simultaneous determination of udenafil, a phosphodiestaerase V inhibitor, and its active metabolite, DA-8164 in free fraction human plasma. The analytes were validated over the range from 1 ng/mL to 100 ng/mL. The precision and accuracy of QC samples were within +-15percent in terms of acceptance ariteria and were stable during the maximum period (24 hr at 4 deg C, 24 hr at room temperature, freeze and thaw at -70 deg C) of analysis. This sensitive and simple method appears to be useful for the pharmacokinetic analysis of the udenafil and DA-8164.

机译：我们建立了一种新的验证方法，用于同时测定Udenafil，磷代酶酶V抑制剂及其活性代谢物，DA-8164在自由级分子等离子体中。将分析物验证在1ng / ml至100ng / ml的范围内。 QC样品的精度和精度在接受结构方面+ -15％内+ -15％，在最大期间稳定（在4℃，24小时，室温下24小时，冷冻和冻解和-70℃）的分析。这种敏感和简单的方法似乎是对Udenafil和DA-8164的药代动力学分析有用。

著录项

来源
《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2009年||共1页
会议地点
作者
Hwa Suk Kim; Seul Oh; Jun-Hwa Shim; Hyang Hee Yang; Won Seok Nam; Seon Jeong Kim; Seo Hyun Yoon; Kyung-Sang Yu; In-Jin Jang;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类 TB994.5-53;
关键词

相似文献

外文文献
中文文献
专利

1. Simultaneous determination of udenafil and its active metabolite, DA-8164, in human plasma and urine using ultra-performance liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study. [J] . Bae SK, Kang MJ, Yeo CW, Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences . 2008,第9期

机译：超高效液相色谱-串联质谱法同时测定人血浆和尿液中的乌地那非及其活性代谢物DA-8164：在药代动力学研究中的应用。
2. Simultaneous determination and determination of sildenafil and its active metabolite in human plasma using LC- MS/MS method [J] . Lin-ling Li, Xiu-jin Zhang, Chao Zheng, Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences . 2020,第10期

机译：利用LC-MS / MS法同时测定人血浆中Sildenafil及其活性代谢物
3. A novel, sensitive and selective method of UPLC/MS-MS for rapid simultaneous determination of midodrine and its active metabolite desglymidodrine in human plasma: Application to support bioequivalence study in healthy human volunteers [J] . Patel Daxesh P., Nair Sneha, Suhagia Bhanubhai N., Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2016,第Null期

机译：一种UPLC / MS-MS的新颖，灵敏，选择性的方法，可快速同时测定人血浆中的米多君及其活性代谢产物desglymidodrine：在支持健康志愿者体内生物等效性研究中的应用
4. Simultaneous Determination of udenafil and its Active Metabolite, DA-8164, in Free Fraction Human Plasma by LC-ESI/MS/MS [C] . Hwa Suk Kim, Seul Oh, Jun-Hwa Shim, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：通过LC-ESI / MS / MS同时测定udenafil及其活性代谢物，DA-8164，自由级分子血浆
5. Validation of a UPLC-MS/MS method for the simultaneous measurement of the antiretroviral drugs atazanavir, darunavir, efavirenz, etravirine, lopinavir, raltegravir, ritonavir from human plasma. [D] . Patel, Rutva. 2012

机译：用于从人血浆中同时测定抗逆转录病毒药物阿扎那韦，达鲁那韦，依非韦伦，依曲韦林，洛匹那韦，拉格列韦，利托那韦的UPLC-MS / MS方法的验证。
6. One-Step Solid Extraction for Simultaneous Determination of Eleven Commonly Used Anticancer Drugs and One Active Metabolite in Human Plasma by HPLC-MS/MS [O] . Shouhong Gao, Zhengbo Tao, Jingya Zhou, 2018

机译：一步固相萃取同时测定人血浆中11种常用抗癌药和1种活性代谢物
7. A Sensitive and Rapid LC–MS-MS Method for Simultaneous Determination of Propafenone and Its Active Metabolite 5-Hydroxypropafenone in Human Plasma and Its Application in a Pharmacokinetic Study [O] . Zhiyan Chi, Ruijuan Liu, Y Li, 2017

机译：一种敏感和快速的LC-MS-MS方法，用于同时测定人血浆中丙酮酮及其活性代谢物5-羟基丙酮及其在药代动力学研究中的应用

Simultaneous Determination of udenafil and its Active Metabolite, DA-8164, in Free Fraction Human Plasma by LC-ESI/MS/MS

摘要

著录项

相似文献

相关主题

期刊订阅