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首页> 外文会议>American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics >Identification of potential biomarkers of esophageal squamous cell carcinoma using quantitative proteomics
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Identification of potential biomarkers of esophageal squamous cell carcinoma using quantitative proteomics

机译：用定量蛋白质组学鉴定食管鳞状细胞癌的潜在生物标志物

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Esophageal cancers are relatively rare form of cancer with less chance of cure. ESCC occurrence is increasing in developing world due to the potential risk factors such as tobacco and alcohol consumption. Our study provides the most comprehensive list of differentially expressed proteins in ESCC till date, which should serve as a resource for systematic validation of candidate biomarkers for early detection of ESCC. Some of the key regulatory molecules which found to be associated with esophageal cancers were identified in this study. Periostin is recently been validated by our group as a molecular marker of ESCC. Molecular biomarkers for diagnosis and prognosis of ESCC are very much essential for further therapeutics. Our study also identified many novel candidate molecules which may serve as potential diagnostic markers.
机译：食管癌是相对罕见的癌症形式，治疗的机会较少。由于烟草和酒精消费等潜在的危险因素，ESCC发生在发展中国家正在增加。我们的研究提供了ESCC中的差异表达蛋白质最全面的差异表达蛋白质列表，该目前应作为候选生物标志物的系统验证，以便早期检测ESCC的资源。在本研究中发现了发现与食管癌有关的一些关键调节分子。最近通过我们的组作为ESCC的分子标记验证了Periostin。 ESCC诊断和预后的分子生物标志物对进一步的治疗方法非常重要。我们的研究还确定了许多可以作为潜在诊断标志物的新型候选分子。

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