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首页> 外文会议>American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics >The CrkRS/CDK12 kinase is activated by a novel isoform of Cyclin K and phosphorylates and the C-terminal domain of RNA Pol II
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The CrkRS/CDK12 kinase is activated by a novel isoform of Cyclin K and phosphorylates and the C-terminal domain of RNA Pol II

机译：CrKRS / CDK12激酶通过细胞周期蛋白K和磷酸化合物的新型同种型和RNA POL II的C末端结构域激活

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摘要

CrkRS (Cdc2-related kinase, Arginine/Serine) or CDK12 (Cyclin Dependent Kinase 12) is a large serine/threonine kinase whose features suggests it may coordinately regulate RNA splicing and transcription (Ko, T.K. et al. J. Cell Sci.114: 2591-2600 (2001)). CrkRS has a N-terminal RS domain suggestive of a role in RNA splicing and has been found to associate with SC35 spliceosome-related nuclear speckles. Its kinase domain is closely related to several cyclin dependent kinases. While CrkRS complexes were known to phosphorylate the C-Terminal Domain (CTD) of RNA Polymerase II in vitro (Ko, T.K. et al. J. Cell Sci.114: 2591-2600 (2001)), the responsible cyclin was not known. However, previous studies have shown that the co-expression of CrkRS and Cyclin L, a cyclin which contains a RS domain, could affect the alternative splicing of a model substrate (Chen, H.H. et al. MCB 26(7): 2736-2745 (2006)).
机译：CRKRS（CDC2相关激酶，精氨酸/丝氨酸）或CDK12（细胞周期蛋白依赖激酶12）是一种大的丝氨酸/苏氨酸激酶，其特征表明它可以协调调节RNA剪接和转录（KO，TK等人J. Cell SCI.114 ：2591-2600（2001））。 CRKRS具有N末端RS域，旨在在RNA剪接中的作用，并已发现与SC35相关的核斑点相关联。其激酶结构域与几个细胞周期蛋白依赖性激酶密切相关。虽然已知CrKRS复合物在体外磷酸化RNA聚合酶II的C-末端结构蛋白域（CTD）（KO，T.K.等人.J.Cell SCI.114：2591-2600（2001）），负责的细胞周期蛋白未知。然而，先前的研究表明，Crkrs和Cyclin L的共表达，含有RS域的细胞周期蛋白，可能会影响模型衬底的替代剪接（Chen，Hh等，MCB 26（7）：2736-2745 （2006））。

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