Open-platform and Targeted MRM Approaches for Prediction of Peg-INF/Ribavirin Treatment Response in Hepatitis C Patients

机译：开放式平台和有针对性的MRM方法，用于预测丙型肝炎患者PEG-INF /利巴韦林治疗反应的方法

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Initial metaprotein model predictive of HCV therapy response has been verified in a 41-patient cohort by unbiased proteomics and 32/41 by MRM quantitation. Remainder of 41-patient cohort data collection ongoing. Additional verification has been performed on 51-patient pediatric cohort using unbiased approach, samples are also to be run with MRM quantitation. Accuracy of MRM quantitation needs to be improved by the use of stable-labeled peptides.

机译：通过UNBIASED蛋白质组学和32/41通过MRM定量，在41患者群组中验证了HCV治疗反应的初始Metaprootein模型。剩余的41例患者队列数据收集正在进行中。使用无偏见的方法对51例患者儿科队列进行了额外的验证，还使用MRM定量来运行样品。使用稳定标记的肽需要改善MRM定量的准确性。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2010年||共1页
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Dubois L.G.; Thompson J.W.; Patel K.; Lucas J.; McCarthy J.; McHutchison J.G.; Moseley M.A.;
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1. Comprehensive Biomarker Discovery Platform Reveals Qualified MRM Assay for Prediction of INF/Ribavirin Treatment Response in Hepatitis C Patients [J] . L.G. Dubois, K. Patel, J.E. Lucas, Journal of biomolecular techniques :JBT. . 2011,第Suppl期

机译：全面的生物标志物发现平台揭示了用于预测丙型肝炎患者INF /利巴韦林治疗反应的合格MRM分析方法
2. Artificial neural networks for the prediction of response to interferon plus ribavirin treatment in patients with chronic hepatitis C. [J] . Maiellaro PA, Cozzolongo R, Marino P Current pharmaceutical design . 2004,第17期

机译：人工神经网络可预测慢性丙型肝炎患者对干扰素加利巴韦林治疗的反应。
3. Artificial Neural Networks for the Prediction of Response to Interferon Plus Ribavirin Treatment in Patients with Chronic Hepatitis C [J] . P. A. Maiellaro R. Cozzolongo P. Marino Current Pharmaceutical Design . 2004,第17期

机译：人工神经网络预测慢性丙型肝炎患者对干扰素加利巴韦林治疗的反应
4. Open-platform and Targeted MRM Approaches for Prediction of Peg-INF/Ribavirin Treatment Response in Hepatitis C Patients [C] . Dubois L.G., Thompson J.W., Patel K., American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：开放式平台和有针对性的MRM方法，用于预测丙型肝炎患者PEG-INF /利巴韦林治疗反应的方法
5. Population pharmacokinetics and efficacy of ribavirin in patients with chronic hepatitis C genotype 1 infection. [D] . Jin, Runyan. 2010

机译：利巴韦林在慢性丙型肝炎基因型1感染患者中的群体药代动力学和功效。
6. Comprehensive Biomarker Discovery Platform Reveals Qualified MRM Assay for Prediction of INF/Ribavirin Treatment Response in Hepatitis C Patients [O] . L.G. Dubois, K. Patel, J.E. Lucas, 2011

机译：全面的生物标志物发现平台揭示了用于预测丙型肝炎患者INF /利巴韦林治疗反应的合格MRM分析方法
7. Abbott RealTime Hepatitis C Virus (HCV) and Roche Cobas AmpliPrep/Cobas TaqMan HCV Assays for Prediction of Sustained Virological Response to Pegylated Interferon and Ribavirin in Chronic Hepatitis C Patients ▿ [O] . Matsuura, Kentaro, Tanaka, Yasuhito, Hasegawa, Izumi, 2008

机译：雅培实时丙型肝炎病毒（HCV）和Roche Cobas AmpliPrep / Cobas TaqMan HCV测定法可预测慢性丙型肝炎患者对聚乙二醇化干扰素和利巴韦林持续的病毒学应答▿

Open-platform and Targeted MRM Approaches for Prediction of Peg-INF/Ribavirin Treatment Response in Hepatitis C Patients

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