Use of UHPLC-MS-MS to assess possible inhibition of human cytochrome P450 enzymes by hops and its major prenylated flavonoids

机译：使用UHPLC-MS-MS来评估啤酒花和其主要戊类黄酮的人细胞色素P450酶的可能抑制

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The female flowers of hops (Humulus lupulus L.) are used in the brewing industry as a flavoring agent for beer. Xanthohumol, a major constituent of hops, is under investigation as a cancer chemoprevention agent, and 8-prenylnaringenin, a metabolite of xanthohumol and a minor constituent of hops, is a potent phytoestrogen. How ever, little is known about possible inte ractions of the se and other prenyl flavonoids with drug metabolism enzymes. To evaluate the potential for cytochrome P450 (CYP) enzyme inhibition by hop extracts and prenylflavonoids, an in vitro assay based on the use of human liver microsome s and UHPLC- MS-MS was validated and applied.

机译：啤酒花（Humulus Lupulus L.）的女性花卉用于酿造工业，作为啤酒的调味剂。啤酒花的主要成分，作为癌症化学预防剂，和8-戊林蛋白，黄嘌呤代谢物和啤酒花的次要组成，是一种有效的植物雌激素。多么众所周知，少数人熟知具有药物代谢酶的SE和其他戊烷类化合物的嵌入型的嵌体型。为了评价细胞色素P450（CYP）酶抑制通过啤酒花提取物和产蛋白抑制的可能性，验证并施加基于使用人肝微粒组和UHPLC-MS-MS的体外测定。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2012年||共2页
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Xi Qiu; Yang Yuan; Dejan Nikolic; Richard B. van Breemen;
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1. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. [J] . Henderson MC, Miranda CL, Stevens JF, Xenobiotica: the fate of foreign compounds in biological systems . 2000,第3期

机译：啤酒花，Hum草中的异戊烯基黄酮类化合物对人P450酶的体外抑制作用。
2. Inhibition of Cytochrome P450 Activities by Sophora flavescens Extract and Its Prenylated Flavonoids in Human Liver Microsomes [J] . Daeun Yim, Min Jung Kim, Yumi Shin, Evidence-based complementary and alternative medicine: eCAM . 2019,第4期

机译：抑制人肝微粒体中的槐花萃取物及其戊烷化黄酮的细胞色素P450活性
3. Inhibition of Cytochrome P450 Activities by Sophora flavescens Extract and Its Prenylated Flavonoids in Human Liver Microsomes [J] . Daeun Yim, Min Jung Kim, Yumi Shin, Evidence-based complementary and alternative medicine: eCAM . 2019,第9期

机译：抑制人肝微粒体中的槐花萃取物及其戊基黄酮的细胞色素P450活性
4. Use of UHPLC-MS-MS to assess possible inhibition of human cytochrome P450 enzymes by hops and its major prenylated flavonoids [C] . Xi Qiu, Yang Yuan, Dejan Nikolic, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：使用UHPLC-MS-MS来评估啤酒花和其主要戊类黄酮的人细胞色素P450酶的可能抑制
5. Inhibition of cytochrome P450 2E1, cytochrome P450 3A6 and cytochrome P450 2A6 by citrus essential oils. [D] . Williamson, Emily Ann. 2010

机译：柑橘精油对细胞色素P450 2E1，细胞色素P450 3A6和细胞色素P450 2A6的抑制作用。
6. Inhibition of Cytochrome P450 Activities by Sophora flavescens Extract and Its Prenylated Flavonoids in Human Liver Microsomes [O] . Daeun Yim, Min Jung Kim, Yumi Shin, 2019

机译：苦参提取物及其异戊烯黄酮对人肝微粒体细胞色素P450活性的抑制作用
7. Inhibition of Cytochrome P450 Activities by Sophora flavescens Extract and Its Prenylated Flavonoids in Human Liver Microsomes [O] . Daeun Yim, Min Jung Kim, Yumi Shin, 2019

机译：抑制人肝微粒体中的槐花萃取物及其戊基黄酮的细胞色素P450活性
8. 2D SMARTCyp Reactivity-Based Site of Metabolism Prediction for Major Drug-Metabolizing Cytochrome P450 Enzymes. [R] . Liu, R., Liu, J., Tawa, G., 2012

机译：基于2D smaRTCyp反应性的代谢位点预测主要药物代谢细胞色素p450酶。

Use of UHPLC-MS-MS to assess possible inhibition of human cytochrome P450 enzymes by hops and its major prenylated flavonoids

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