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Simultaneous Analysis of 15 Selected Psychoactive Drugs from Different Groups in Human Urine Samples By Isotope Dilution Tandem-Mass Spectrometry

机译:同位素稀释串联光谱法同时分析来自人类尿液中不同群体的15种选定的精神活性药物

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摘要

A unique and reliable method for analyzing selected 15 psychoactive drugs from different groups in urine samples developed. The reagents and extraction solvent mixture for sample preparation and was modified to increase recovery for all analytes. The developed method succesfully validated in terms of sensitivity, linearity, accuracy, precision and specifity. We analyzed most important members of amphetamines, benzodiazepines, opiates and cannabinoids in single run by using this method. This method can be easily extended for more psychoactive drugs which have similar chemical structure and properties.
机译:一种独特而可靠的方法,用于分析所选择的15种来自不同群体中的尿样中的精神活性药物。试剂和萃取溶剂混合物用于样品制备,被修饰以增加所有分析物的恢复。开发方法以灵敏度,线性,准确性,精度和规格而成功验证。通过使用这种方法,我们分析了单一运行中最重要的安非胺,苯二氮藻,蛋白质和大麻素的成员。对于具有类似化学结构和性质的更多精神活性药物,可以容易地扩展该方法。

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