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首页> 外文会议>American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics >Determination of the pyrethroid deltamethrin in rat plasma and brain homogenate using gas chromatography (GC) negative chemical ionization mass spectrometry
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Determination of the pyrethroid deltamethrin in rat plasma and brain homogenate using gas chromatography (GC) negative chemical ionization mass spectrometry

机译：用气相色谱法测定大鼠血浆和脑匀浆中拟除虫菊酯溴氰菊酯，负化学电离质谱法

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A novel bioanalytical method for rapid quantification of deltamethrin in small samples of rat plasma and rat brain homogenate was successfully developed and validated to current FDA guidelines. The method was used to successfully monitor the uptake and elimination of deltamethrin in plasma and brain following oral dosing of rats. These data provided key toxicokinetic parameters from concentration/ time profiles that will aid future studies in the construction of physiological models to accurately predict the target organ dosimetry and neurotoxic potential of pyrethroidsin children and adults for real life exposure scenarios. The method will be applied to the quantification of other pyrethroids in plasma, brain, liver, skin, muscle and fat.
机译：成功开发了一种新的大鼠血浆小鼠血浆和大鼠脑匀浆中的溴氰菊酯的新型生物分析方法，并验证到当前的FDA指南。该方法用于成功监测血浆和大脑中血浆中溴氰菊酯的摄取和消除，术后大鼠口服给药。这些数据提供了来自集中/时间曲线的关键毒物动力学参数，这些参数将帮助未来研究生理模型的建设，以准确预测拟除虫松儿童和成人的靶器官剂量剂和神经毒性潜力，以实现现实生活的暴露场景。该方法将应用于血浆，脑，肝，皮肤，肌肉和脂肪中其他拟除虫菊酯的定量。

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