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首页> 外文会议>SPIE Conference on Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues >Time-gated real-time bioimaging system using multicolor microsecond-lifetime silica nanoparticles
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Time-gated real-time bioimaging system using multicolor microsecond-lifetime silica nanoparticles

机译：使用多色微秒寿命二氧化硅纳米粒子的时间门控实时生物分析系统

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摘要

In advanced cytometry, a fundamental challenge for rapid specific detection of rare-event micro-organisms is the autofluorescence noise from the complex biological samples. Time-gated luminescence can effectively discriminate labeled cells from autofluorescence background. Recently, a real-time true-colour time-gated luminescence microscopy system has been developed based on the synchronization of a solid-state excitation source and a super-fast optical shutter. We also developed a variety of ultra-bright silica nano-biolabels with multiple luminescence colours and controllable lifetimes in microsecond range. These developments allowed the development of an advanced cell analysis system for real-time background-free imaging and rare-event counting of microsecond-lifetime multi-colour labelled water-borne pathogens.
机译：在高级细胞术中，对稀有事件微生物的快速特异性检测的根本挑战是复杂生物样品的自发荧光噪声。时间门控发光可以有效地区分来自自发荧光背景的标记细胞。最近，已经基于固态激励源和超快速光学快门的同步开发了实时真正的时隙发光显微镜系统。我们还开发了各种超亮二氧化硅纳米Biolabels，具有多种发光颜色和可控的寿命在微秒范围内。这些发展允许开发一个高级细胞分析系统，用于实时背景自由成像和微终寿命多色标记的水传播病原体的稀有事件计数。

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