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MEG Slow Wave Dipole Density (SWDD) in Presurgical Evaluation of Epilepsy Patients: Preliminary Results of a Prospective Study

机译:癫痫评估癫痫评估患者的MEG慢波偶极密度(SWDD):前瞻性研究的初步结果

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The aim of this prospective study is to examine the potential contribution of SWDD localisation in clinical preoperative epilepsy focus localisation. Methods Preoperative MEG-SWDD localisations are calculated and overlaid on MR-images of pharmaco-resistant epilepsy patients undergoing presurgical focus localisation evaluation. For all 10 patients who have been operated within at least 6 months, postsurgical outcomes available up to now, are discussed. SWDD localisation results are compared to other preoperative findings and to MEG-spike results and are correlated to postoperative outcome (Engel) after 6 months or 12 months. Results 7 of 10 patients showed significant local increase of SWDD. In these SWDD localisation results were always concordant with preoperative findings. All 7 patients were postoperatively seizure-free or had a worthwhile improvement of seizure situation. 3 of 10 patients showed no significant local increase of SWDD and, therefore, were without SWDD result. Comparison to MEG spike results: Among these 7 patients, 6 showed MEG-spike concordant localisations, one had no spikes in the MEG. Conclusions SWDD is able to localise brain areas exhibiting pathological slow wave activity and might become a useful tool for preoperative epilepsy diagnosis.
机译:这项前瞻性研究的目的是研究SWDD定位在临床术前癫痫聚焦本地化中的潜在贡献。方法计算术前MEG-SWDD定位,并覆盖在经历过鉴别焦点定位评估的药物抗癫痫患者的MR图像上。对于所有10名已在至少6个月内运营的患者,讨论了现在可用的后期结果。 SWDD定位结果与其他术前发现和MEG-Spike结果进行了比较,并且在6个月或12个月后与术后结果(埃涅)相关。结果10例患者的7例患者显着增加了SWDD的局部增加。在这些SWDD本地化结果始终是术前发现的一致性。所有7名患者都是无潜在的癫痫发作或有价值的癫痫发作。 10名患者中有3名患者没有显着的SWDD局部增加,因此没有SWDD结果。与Meg Spike结果相比:在这7例患者中,6例显示了Meg-Spike的协调定位,梅格没有尖刺。结论SWDD能够本地化表现出病理缓慢波动活动的大脑区域,可能成为术前癫痫诊断的有用工具。

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