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首页> 外文会议>Annual and International Meeting of the Japanese Association for Animal Cell Technology >The Differentiation of C2C12 Cells to Myotube by Paraquat
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The Differentiation of C2C12 Cells to Myotube by Paraquat

机译：用百草枯将C2C12细胞的分化为myoTube

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Paraquat (1, 1 '-dimethyl-4, 4'-bypiridinium)is one of herbicide, often used in many counties. However, in some case with wrong usage of paraquat, paraquat shows toxicity against human, especially on framer. In these cases, paraquat produces reactiveoxygen species (ROS) to show its toxicity. One of important toxicity in paraquat against mammal is to induce Parkinsonism. 1-methyl-4-phenylpyridinium (MPP+), the structure is similar to paraquat have been known to induce Parkinsonism. MPP+ is metabolized from l-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyridine (MPTP), impurity in stimulant. Because paraquat and MPP+ have similar structure, paraquat also is concerned with Parkinson's disease [M]. It is also known that paraquat activates Mitogen-activated protein kinase kinase (MEK) - extracellular signal-regulated kinases (ERK) and c-Jun N-terminal kinases (JNK) in brain neuroblasts. These kinases are known to concerned with the differentiation of cells to macrophages, adipocytes and muscle, suggesting the importance of these kinases in the differentiation of these kind of tissues. Paraquat is known to induce injury on the lungs. Then paraquat induces the differentiation of interstitial cells into muscle cells in the lung of monkeys suggesting that paraquat perturbs the differentiation of muscle cells.
机译：百草枯（1,1'-二甲基-4,4'-bypiridinium）是除草剂之一，通常用于许多县。然而，在某些情况下，百草枯的使用错误，百草枯显示毒性对人的毒性，尤其是在成帧上。在这些情况下，百草枯产生反应氧基物种（ROS）以显示其毒性。百草枯对哺乳动物的重要毒性之一是诱发帕金森主义。 1-甲基-4-苯基吡啶（MPP +），该结构类似于已知帕金森毒素。 MPP +从L-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP），纯度溶避中的杂质代谢。因为百草枯和MPP +具有相似的结构，所以百草枯也关注帕金森病[M]。还已知百草枯激活促丝瘤激活的蛋白激酶激酶（MEK） - 细胞外信号调节激酶（ERK）和C-JUN N-末端激酶（ERK）和C-JUN N-末端激酶（JNK）。已知这些激酶涉及细胞对巨噬细胞，脂肪细胞和肌肉的分化，表明这些激酶在这些组织的分化中的重要性。已知百草酸诱导肺部损伤。然后百草酸诱导间质细胞的分化为猴子的肺部肌细胞，表明百叶菌扰乱了肌细胞的分化。

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