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HUMAN HEALTH RISK OF HEAVY METALS THROUGH FISH AND SHELLFISH INGESTION: A CASE STUDY FOR THE ARABIAN GULF

机译:通过鱼和贝类摄入的人类健康风险:阿拉伯海湾的案例研究

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Human exposure to heavy metals through ingestion of fish and shellfish from the Arabian Gulf was predicted. Risks associated with such exposures were assessed. Concentrations of ten heavy metals: cadmium (Cd), arsenic (As), chromium (Cr), copper (Cu), mercury (Hg), manganese (Mn), nickel (Ni), lead (Pb), vanadium (V) and zinc (Zn) were characterized for 35 marine fish and shellfish species from the Arabian Gulf region for the period of 1988-2010. Ingestion patterns of seafood were developed. Cancer risks were estimated from arsenic (As) exposure through the oral route, while other metals were not reported to be human carcinogen through oral route. Hazard indices from these metals through fish ingestion were predicted. Chronic daily intakes (CDI) of these metals were estimated to be in the range of 1.55x10~(-06)-5.72×10~(04) mg/kg/day. This study estimated cancer risks in the range of 6.7×10~(-11) - 1.1 ×10~(-04) with an average of 2.1×10~(06). Cumulative hazard index was estimated to be 0.159 (range: 0.01-1.59). Approximately 0.18% of the exposed populations had higher hazard index than the U.S. Environmental Protection Agency regulatory limit of unity. The probability of one cancer incident in 1 million populations from lifetime exposure to arsenic through fish ingestion was predicted to be 0.49. Presence of other metals and inorganic/organic chemicals and complexes in fish and shellfish may impose additional risks to human. Through comprehensive understanding of cumulative exposures and risks from all contaminants, appropriate measures can be adopted to better protect human health in the Arabian Gulf region.
机译:预计通过摄入鱼和贝类从阿拉伯海湾的鱼和贝类接触重金属的人。评估与这种暴露有关的风险。十个重金属的浓度:镉(Cd),砷(As),铬(Cr),铜(Cu),汞(Hg),锰(Mn),镍(Ni),铅(Pb),钒(V)锌(Zn)的特征在于1988 - 2010年阿拉伯海湾地区的35个海洋鱼类和贝类物种。开发了海鲜的摄取模式。通过口腔途径估计癌症(AS)暴露的癌症风险,而其他金属尚未通过口腔途径据报道是人类致癌物质。预测来自这些金属通过鱼类摄取的危险指数。这些金属的慢性每日摄入量(CDI)估计为1.55x10〜(-06)-5.72×10〜(04)mg / kg /天。这项研究估计了6.7×10〜(-11) - 1.1×10〜(-04)范围内的癌症风险,平均为2.1×10〜(06)。累积危险指数估计为0.159(范围:0.01-1.59)。大约0.18%的暴露群体的危险指数较高,而不是美国环境保护局的统一规律限制。预计通过鱼摄入终身暴露于砷的100万个癌症中的癌症的可能性是0.49。鱼类和贝类中其他金属和无机/有机化学品和复合物的存在可能对人类施加额外的风险。通过全面了解所有污染物的累积暴露和风险,可以采用适当措施来更好地保护阿拉伯海湾地区的人类健康。

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