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>COMPACTION AND ANISOFTROPY INDUCED BY REMODELING OF THE COLLAGEN NETWORK S STATE OF TENSION-COMPRESSION TRANSITION
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COMPACTION AND ANISOFTROPY INDUCED BY REMODELING OF THE COLLAGEN NETWORK S STATE OF TENSION-COMPRESSION TRANSITION
Extracellular matrix remodeling is ubiquitous in connective, musculoskeletal and cardiovascular tissues. The collagen network can thereby not only remodel its orientation [l] but also its stress-free configuration. This stress-free configuration can be described by the so-called transition stretch - the stretch above which a fiber begins to bear load. Remodeling of collagen crimp has been shown to be involved in long bone growth [2], contracture, scar pathologies, collagen gel compaction and can be cell mediated or occur via cell-independent mechanisms |3,4,5]. An algorithm is presented that addresses remodeling in terms of stress-free configurations and angular orientations of collagen reinforced tissues and bioniatcrials at finite deformations. It is applied to initially isotropic cruciform f 6] tissue equivalents to investigate the evolution towards anisotropic fiber distributions induced by contraction of the gels.
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