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首页> 外文会议>Congress of the International Society for Mushroom Science >Radioprotective Effects of Agaricus blazei Murrill ( Himematsutake)
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Radioprotective Effects of Agaricus blazei Murrill ( Himematsutake)

机译：姬松茸（Hamematsutake）的辐射防护作用

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Agarius blazei Murrill (Himematsutake) had great value as a functional food because it was obvious with the experiment which was performed using mice that the (1-6)-β-D-glucan-protein-complex had an anti-tumor effect. Our previous studies revealed that Agaricus blazei Murrill had several anti-tumor effects. In this study, we examined a radioprotective effect of a heatextracted Agaricus blazei Murrill (ABM-FD) using the survival rate of male ICR mice exposed to 8. 0 Gy whole-body X-ray irradiation. The ABM-FD dose is 500 mg/kg body weight per os. The groups oral administered ABM-FD was classified into three groups according to the day of the first irradiation; the group that was administered before 3 days from irradiation, the group that was administered at same day of irradiation and the group that was administered 3 days after irradiation. They say that the cause of death by irradiation was gastrointestinal damage, so we examined whether an enteric bacteria of the mice blood was cultured on an agar medium or not. The survival rates of all administered groups were significantly increased against the control group. The survival rate of the group administered 3 days after irradiation was 83%. In the all dead mice, the enteric bacteria was detected in these blood cultures, then it was suggested that these mice became a bactriaemia. According to the experimental results, it was suggested that the radiation death was caused by radiation intestinal damage, and the subjects that had continuous oral administration of ABM-FD might have enhanced the recovery capability from intestinal damage after irradiation. These mechanisms haven' t been still revealed, but it was strongly suggested that ABM-FD is suitable for a strong radioprotective agent.
机译：Agarius Blazei Murrill（Philematsutake）具有很大的价值作为功能性食物，因为使用小鼠进行的实验显而易见的是（1-6）-β-D-葡聚糖蛋白 - 复合物具有抗肿瘤作用。我们以前的研究表明，姬松茸穆里尔有几种抗肿瘤作用。在这项研究中，我们使用暴露于8. 0 GY全体X射线照射的雄性ICR小鼠的存活率检查了热激动的伞菌Blazei Murrill（ABM-FD）的放射性保护作用。 ABM-FD剂量每OS为500mg / kg体重。将群体施用的ABM-FD根据第一次辐照的一天分为三组;在辐照3天之前进行的组，该组在照射的同一天给药和辐照后3天施用的组。他们说，辐照死亡原因是胃肠道损伤，因此我们检查了是否在琼脂培养基上培养小鼠血液的肠道细菌。对照组所有施用基团的存活率显着增加。辐照后3天给药的本组的存活率为83％。在所有死鼠中，在这些血液培养物中检测到肠溶细菌，然后建议这些小鼠成为BacraTiaMia。根据实验结果，建议辐射死亡是由辐射肠损害引起的，并且具有连续口服给药的受试者可能会在辐照后从肠道损伤中提高回收能力。这些机制仍然被揭示，但强烈建议ABM-FD适用于强烈的辐射防护剂。

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