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首页> 外文会议>Proceedings of the 18th congress of the International Society for Mushroom Science >Radioprotective Effects of Agaricus blazei Murrill ( Himematsutake)
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Radioprotective Effects of Agaricus blazei Murrill ( Himematsutake)

机译：姬松茸的辐射防护作用（姬松茸）

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Agarius blazei Murrill (Himematsutake) had great value as a functional food because it was obvious with the experiment which was performed using mice that the (1-6)-β-D-glucan-protein-complex had an anti-tumor effect. Our previous studies revealed that Agaricus blazei Murrill had several anti-tumor effects. In this study, we examined a radioprotective effect of a heatextracted Agaricus blazei Murrill (ABM-FD) using the survival rate of male ICR mice exposed to 8. 0 Gy whole-body X-ray irradiation. The ABM-FD dose is 500 mg/kg body weight per os. The groups oral administered ABM-FD was classified into three groups according to the day of the first irradiation; the group that was administered before 3 days from irradiation, the group that was administered at same day of irradiation and the group that was administered 3 days after irradiation. They say that the cause of death by irradiation was gastrointestinal damage, so we examined whether an enteric bacteria of the mice blood was cultured on an agar medium or not. The survival rates of all administered groups were significantly increased against the control group. The survival rate of the group administered 3 days after irradiation was 83%. In the all dead mice, the enteric bacteria was detected in these blood cultures, then it was suggested that these mice became a bactriaemia. According to the experimental results, it was suggested that the radiation death was caused by radiation intestinal damage, and the subjects that had continuous oral administration of ABM-FD might have enhanced the recovery capability from intestinal damage after irradiation. These mechanisms haven' t been still revealed, but it was strongly suggested that ABM-FD is suitable for a strong radioprotective agent.
机译：姬松茸（姬松茸）作为功能性食品具有很高的价值，因为在使用小鼠进行的实验中显而易见的是（1-6）-β-D-葡聚糖-蛋白质复合物具有抗肿瘤作用。我们以前的研究表明姬松茸具有几种抗肿瘤作用。在这项研究中，我们使用暴露于8. 0 Gy全身X射线照射的雄性ICR小鼠的存活率，研究了热提取的姬松茸（ABM-FD）的辐射防护作用。 ABM-FD剂量为每剂500 mg / kg体重。口服ABM-FD的组根据第一次照射的日期分为三组。在照射后3天之前给予的组，在照射日当天给予的组和照射后3天给予的组。他们说，辐射造成的死亡原因是胃肠道损害，因此我们检查了小鼠血液的肠细菌是否在琼脂培养基上培养。与对照组相比，所有给药组的存活率均显着提高。放射后3天给药组的存活率为83％。在所有死亡的小鼠中，在这些血液培养物中检测到肠细菌，然后提示这些小鼠成为细菌血症。根据实验结果，认为放射线死亡是由放射线肠损伤引起的，并且连续口服ABM-FD的受试者可能增强了放射线对肠损伤的恢复能力。这些机制尚未被揭示，但是强烈建议ABM-FD适用于强辐射防护剂。

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