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NMR AND MOLECULAR DYNAMICS STRUCTURAL STUDIES OF GLYCOSAMINOGLYCANS AND THEIR INTERACTION WITH MIDKINE AND PLEIOTROPHIN

机译：糖胺聚糖的NMR和分子动力学结构研究及其与中脑和肺炎的相互作用

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Midkine (MK) and Pleiotrophin (PTN) are members of a family of Glycosaminoglycan-binding growth factors which play an important role in early central nervous system development, as well as in pathologies as inflammation and cancer. Recent studies have demonstrated that both cytokines strongly bind to some glycosaminoglicans (GAGs) as heparin and chondroitin sulfate chains (CS), giving rise complexes that can modulate important biological processes [1] (Figure 1). For this reason, have been carried out studies using fluorescence polarization which has allowed us to characterize protein-ligand binding of glycomimetics of several GAGs in solution[2].

机译：中核（MK）和Pleiotrochin（PTN）是一家糖胺聚糖的成员，其在早期中枢神经系统发育中起重要作用，以及病理和炎症和癌症。最近的研究表明，两种细胞因子与一些糖蛋白酶（GAG）与肝素和硫酸软骨素链（CS）强烈结合，这给出了可以调节重要生物过程的络合物[1]（图1）。因此，已经通过荧光偏振进行了研究，该研究已经使我们在溶液中表征含有几个GAG的甘氨酸蛋白质 - 配体结合[2]。

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《International Carbohydrate Symposium》|2018年|832 p.|共1页
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Myriam Torres Rico; Pedro M. Nieto; Jose Luis de Paz;
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中图分类碳水化合物、糖;
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1. Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions [J] . The Biochemical Journal . 2015,第Pta1期

机译：溶液NMR表征趋化因子CXCL8 / IL-8单体和二聚体结合到糖胺聚糖：结构可塑性介导差异结合相互作用
2. Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions [J] . Krishna Rajarathnam, Philip?D. Mosier, Prem Raj?B. Joseph, The biochemical journal . 2015,第1期

机译：趋化因子CXCL8 / IL-8单体的溶液NMR表征以及与糖胺聚糖的二聚体结合：结构可塑性介导不同的结合相互作用
3. Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions [J] . Joseph Prem Raj B., Mosier Philip D., Desai Umesh R., The Biochemical Journal . 2015,第Pta1期

机译：趋化因子CXCL8 / IL-8单体的溶液NMR表征以及与糖胺聚糖的二聚体结合：结构可塑性介导不同的结合相互作用
4. NMR AND MOLECULAR DYNAMICS STRUCTURAL STUDIES OF GLYCOSAMINOGLYCANS AND THEIR INTERACTION WITH MIDKINE AND PLEIOTROPHIN [C] . Myriam Torres Rico, Pedro M. Nieto, Jose Luis de Paz International Carbohydrate Symposium . 2018

机译：糖胺聚糖的NMR和分子动力学结构研究及其与中脑和肺炎的相互作用
5. NMR studies of fibronectin peptides and their interactions with heparin and related glycosaminoglycans. [D] . Swanson, Mark Gunnard. 1998

机译：纤连蛋白肽的NMR研究及其与肝素和相关糖胺聚糖的相互作用。
6. Combining NMR and Molecular Dynamics Studies for Insights into the Allostery of Small GTPase–Protein Interactions [O] . Liqun Zhang, Sabine Bouguet-Bonnet, Matthias Buck -1

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7. Structural studies on yeast eIF5A using biomolecular NMR and molecular dynamics [O] . Sigauke Lester Takunda 2015

机译：酵母eIF5a的结构研究使用生物分子NmR和分子动力学
8. NMR (Nuclear Magnetic Resonance) Study of the Molecular Interactions and Dynamic Behavior in Polymer-Diluent Blends in the Solid State [R] . Inglefield, P. T., Jones, A. A. 1988

机译：NmR（核磁共振）研究固态聚合物 - 稀释剂共混物的分子相互作用和动力学行为

NMR AND MOLECULAR DYNAMICS STRUCTURAL STUDIES OF GLYCOSAMINOGLYCANS AND THEIR INTERACTION WITH MIDKINE AND PLEIOTROPHIN

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