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首页> 外文会议>International Carbohydrate Symposium >SYNTHESIS OF NOVEL D-GLUCURONAMIDE-BASED TRIZOLE NUCLEOSIDES AS POTENTIAL ANTI-ALZHEIMER AGENTS
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SYNTHESIS OF NOVEL D-GLUCURONAMIDE-BASED TRIZOLE NUCLEOSIDES AS POTENTIAL ANTI-ALZHEIMER AGENTS

机译：基于新型D-葡萄糖醛酰胺的三唑核苷作为潜在抗阿尔茨海默试剂的合成

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摘要

The synthesis of analogues of nucleosides occupies a relevant place in medical chemistry due to the diversity of biological activities that there compounds are prone to exhibit. Some of these molecules display anticancer and antiviral activities, among which several examples reached clinical application [1]. We have previously showed the potential of nucleosides from D-glucuronamide derivatives [2] and of 6'-isonucleosides [3, 4], including a triazole derivative [3], to inhibit cholinesterases. These enzymes are relevant therapeutic targets for Alzheimer's disease, a neurodegenerative pathology that is the sixth leading cause of death worldwide.
机译：由于有易于表现出的生物活性的多样性，核苷类似物的合成占据了医学化学中的相关位置。其中一些分子显示出抗癌和抗病毒活性，其中几种实施例达到临床应用[1]。我们以前展示了来自D-葡糖醛酰胺衍生物[2]和6'-异核苷[3,4]的核苷的潜力，包括三唑衍生物[3]，以抑制胆碱酯酶。这些酶是阿尔茨海默病的相关治疗目标，是神经变性病理学，即全世界的第六个主要死因。

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