• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food Environmental Technologies >Electrochemogene Therapy as an Effective and Safe Treatment of Canine Cutaneous Mast Cell Tumors
【24h】

Electrochemogene Therapy as an Effective and Safe Treatment of Canine Cutaneous Mast Cell Tumors

机译：电化学疗法作为犬皮肤肥大细胞瘤的有效和安全的治疗方法

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of presented study was to determine efficacy and safety of combined electrochemotherapy and elec-trogene therapy in treatment of canine cutaneous mast cell tumors. 18 tumor nodules in 18 patients were treated with combination of intratumoral ECT using cisplatin and peritu-moral intradermal IL-12 EGT. Complete response was achieved in 72% of patients (objective response in 78%), with 100% complete response rate in smaller tumors (<2cm3). In patients which presented without metastases before treatment (14/18), the disease did not progress and tumors did not metas-tatise despite 6 of them being higher grade tumors. Poor response to therapy (progression of disease) was observed in only 3 patients with pre-existing metastases and higher clinical stage of disease. However, one patient with metastatic disease was completely cured and remained tumor free for over 2 years. Systemic release of hIL-12 was detected in 88% of examined patients and 70% of patients responded with elevation of IFN-y up to 3 months after therapy. The treatment didn't cause any local or systemic side effects. In conclusion, electrochemogene therapy with a combination of IL-12 and cisplatin is highly effective and safe antitumor treatment in canine cutaneous mast cell tumors.
机译：提出的研究的目的是确定组合电化学疗法和ELEC- Trogene治疗治疗犬皮肤肥大细胞肿瘤的疗效和安全性。 18例肿瘤结节18例患者用Cisplatin和Peritu-Moral皮内IL-12 EGT进行肿瘤内切入治疗。在72％的患者（78％的客观反应）中取得了完全反应，较小肿瘤（<2cm3）中的100％完全响应率。在治疗前没有转移的患者（14/18）中，尽管其中6个是更高的肿瘤，但疾病的疾病没有进展，并且肿瘤也没有达到达到的。仅在3名患者预先存在的转移和临床疾病患者中观察到治疗的反应差（疾病进展）。然而，一个患有转移性疾病的患者被完全固化并保持肿瘤超过2年。在88％的检查患者中检测到HIL-12的全身释放，70％的患者在治疗后的IFN-Y的升高至3个月后作出反应。治疗没有造成任何局部或全身副作用。总之，具有IL-12和顺铂组合的电化学疗法在犬皮肥大细胞瘤中具有高效和安全的抗肿瘤治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号