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首页> 外文会议>National SBIR/STTR conference >Comparative and Synergistic Studies of Antibacterial Effect of ZnO Nanoparticles and Antibiotics for Pathogens in Drinking Water
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Comparative and Synergistic Studies of Antibacterial Effect of ZnO Nanoparticles and Antibiotics for Pathogens in Drinking Water

机译：ZnO纳米粒子抗菌作用对饮用水抗生素抗菌作用的比较与协同研究

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The goal of this study was to determine the antibacterial efficiency of zinc oxide nanoparticles against various Gram negative bacteria isolated from local sources of drinking water. We have been able to isolate and identify Escherichia coli, Serratia marcescens, Enterobacter cloacae, Cronobacter sakazakii, Pseudomonas aeruginosa, klebsiella pneumoniae and Aeromonas hydrophila. A variety of microbiological tests were carried out using different concentrations and working volumes of zinc oxide nanoparticles with average size of 35 nm. Earlier results have already been reported (TechConnect Briefs 2015, Vol. 1). Current Result showed the antibacterial activity of different concentrations (0, 100, 200, 300 & 500 mg/ml) of zinc oxide nanoparticles against P. aeruginosa and k. pneumoniae. Highest zone of inhibition i.e. 25 mm was observed at 500 mg/ml against P. aeruginosa while K. pneumoniae showed a 20 mm zone of inhibition at same concentration. When different volumes (0, 10, 20, 30, 40, 50, 60 ul) of ZnO NPs were tested the highest zone of inhibition i.e. 23 mm was observed at 60 ul against P. aeruginosa while K. pneumoniae showed 22 mm zone of inhibition. Antibiotic susceptibility of various antibiotics was also tested in combination with ZnO nanoparticles against these water borne bacteria. Results revealed that antibiotic efficacy of Erythromycin (ERYC) was enhanced by the addition of ZnO NPs (5 μl) of 500 mg/ml. Erythromycin showed only DZI of 7 mm against E. cloacae but the same antibiotic along with ZnO NPs showed zone of inhibition of 12 mm against E. cloacae showing a substantial increase. Therefore ZnO NPs have the potential for their use as a very effective antibacterial agent for antibiotic resistant bacteria and eventually for water purification.
机译：该研究的目的是确定氧化锌纳米颗粒对各种革兰阴性细菌的抗菌效率，从局部饮用水中分离。我们已经能够孤立和识别大肠杆菌，Serratia Marcescens，肠杆菌肠杆菌，Cronobacter Sakazakii，假单胞菌Aeruginosa，Klebsiella肺炎和Aeromonas疏水米。使用不同浓度和工作体积的氧化锌纳米颗粒，平均尺寸为35nm的各种微生物检验。已经报告了早期的结果（TechConnect 2015年，第1卷。1）。目前的结果表明，不同浓度（0,100,200,300毫克/ ml）的锌氧化物纳米颗粒的抗菌活性针对铜绿假单胞菌和k。肺炎。最高的抑制区I.在500mg / ml的情况下，针对P.铜绿假单胞菌观察到25mm，而K.肺炎患者在相同浓度下显示出20mm的抑制区。当测试不同的体积（0,10,20,30,40,50,60μl）ZnO NPS时，在60μl反对P.铜绿假单胞菌的情况下观察到抑制的最高区域，而K.Pneumoniae显示22毫米抑制。还与ZnO纳米颗粒组合测试各种抗生素的抗生素敏感性，与这些水源性细菌组合。结果表明，通过加入500mg / ml的ZnO NPS（5μl）来增强红霉素（ERYC）的抗生素疗效。红霉素仅表现出7毫米的Dzi对抗E. Cloacae，但与ZnO NPS相同的抗生素显示出12mm的抑制区，反对E. Cloacae显示出大量增加。因此，ZnO NPS具有它们用作抗生素抗菌细菌的非常有效的抗菌剂，最终用于净水。

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