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首页> 外文会议>Annual Applied Science and Engineering Conference >Chemopreventive Activity of Kola (Cola Accuminata) Seed Ethanol Extract in Mice Induced by Cyclophosphamide
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Chemopreventive Activity of Kola (Cola Accuminata) Seed Ethanol Extract in Mice Induced by Cyclophosphamide

机译：环磷酰胺诱导的小鼠中KOLA（可乐偶然型）种子乙醇提取物的化学预防活性

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Cola accuminata or kola is one of the plants that have activity as anticancer. Previous research has shown that the content of hexane extract from Cola accuminata seeds can kill 100% of breast cancer and prostate cancer. The objective of this study was to demonstrate the presence of chemopreventive activity of ethanol extract of cola seeds in cyclophosphamid-induced test animals. The experiment was conducted using experimental method using healthy mice. The kola seeds were extracted macerated for 48 hours with ethanol solvent. On the first day, the test animal induced by cyclophosphamide with a dose of 50 mg/kgBW intraperitoneal. Ethanol extracts of kola seeds were administered for test animals at doses of 200.400 and 800 mg /kgBW for 2 days then animal was killed and dissected, blood drawn for hematocrit and femoral bone examination for micronucleus examination. Based on result of research known ethanol extract of kola bean able to increase hematocrit value but not statistically significant and on micronucleus observations showed a statistically significant decrease in the amount of micronucleus (P<0,05) with the best activity seen at doses of 800 mg/kgBW. The results concluded that the extract ethanol kola seeds have chemopreventive activity at dose 800 mg /kgBW.
机译：Cola Accuminata或Kola是患有抗癌活动的植物之一。以前的研究表明，来自可乐录像种子的己烷提取物的含量可以杀死100％的乳腺癌和前列腺癌。本研究的目的是证明在环膦酰胺诱导的测试动物中的可乐种子的乙醇提取物的化学预防活性存在。使用健康小鼠使用实验方法进行实验。将Kola种子用乙醇溶剂浸渍48小时。第一天，由环磷酰胺诱导的试验动物，剂量为50mg / kgbw腹膜内。乙醇提取物的KOLA种子施用于200.400和800mg / kgbw的剂量2天的试验动物，然后动物被杀死并解剖，用于血细胞比容和股骨骨检查的血液检查微核检查。基于研究的结果，能够增加血细胞比容值但没有统计学上显着和微核观察结果的乙醇提取物，观察结果表明微核（P <0.05）的数量有统计学显着的降低，其剂量为800剂的最佳活性mg / kgbw。结果得出结论，提取物乙醇kola种子在800mg / kgbw的剂量下具有化学预防活性。

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