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首页> 外文会议>International Workshop on Smart Ultrasound Imaging >Longitudinal Analysis of Fetal MRI in Patients with Prenatal Spina Bifida Repair
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Longitudinal Analysis of Fetal MRI in Patients with Prenatal Spina Bifida Repair

机译：产前脊柱脊柱型胎儿修复患者胎儿MRI的纵向分析

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摘要

Open spina bifida (SB) is one of the most common congenital defects and can lead to impaired brain development. Emerging fetal surgery methods have shown considerable success in the treatment of patients with this severe anomaly. Afterwards, alterations in the brain development of these fetuses have been observed. Currently no longitudinal studies exist to show the effect of fetal surgery on brain development. In this work, we present a fetal MRI neuroimaging analysis pipeline for fetuses with SB, including automated fetal ventricle segmentation and deformation-based morphometry, and demonstrate its applicability with an analysis of ventricle enlargement in fetuses with SB. Using a robust super-resolution algorithm, we reconstructed fetal brains at both pre-operative and post-operative time points and trained a U-Net CNN in order to automatically segment the ventricles. We investigated the change of ventricle shape post-operatively, and the impacts of lesion size, type, and GA at operation on the change in ventricle shape. No impact was found. Prenatal ventricle volume growth was also investigated. Our method allows for the quantification of longitudinal morphological changes to fully quantify the impact of prenatal SB repair and could be applied to predict postnatal outcomes.
机译：Open Spina Bifida（SB）是最常见的先天性缺陷之一，可以导致大脑发育受损。新出现的胎儿手术方法在治疗这种严重异常的患者方面表现出相当大的成功。之后，已经观察到这些胎儿的大脑发展的改变。目前没有纵向研究表明胎儿手术对脑发育的影响。在这项工作中，我们提出了一种胎儿MRI神经影像分析分析管线，用于具有Sb的胎儿，包括自动胎儿心室分割和基于变形的形态学，并展示其适用性与SB胎儿的心室扩大的应用性。使用稳健的超分辨率算法，我们在术前和操作后的时间点重建胎儿大脑，并培训了U-Net CNN，以便自动分割心室。我们调查了可操作性的心室形状的变化，以及病变大小，型和GA的影响在脑室形状的变化下的操作。没有发现影响。还研究了产前脑室体积生长。我们的方法允许定量纵向形态变化，以完全量化产前SB修复的影响，并且可以应用于预测产后结果。

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