The Role of Protein Electrostatics in Facilitating the Catalysis of DEAD-box Proteins

机译：蛋白质静电方法在促进死箱蛋白催化的作用

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Protein electrostatic states have been demonstrated to play crucial roles in catalysis, ligand binding, protein stability, and in the modulation of allosteric effects. Electrostatics states are demonstrated to appear conserved among DEAD-box motifs and evidence is presented that the structural changes that occur to DEAD box proteins upon ligand binding alter the DEAD-box motif electrostatics in a way the facilitates the catalytic role of the DEAD-box glutatmate.

机译：已经证明蛋白质静电状态在催化作用，配体结合，蛋白质稳定性以及在变构效果的调节中起着至关重要的作用。静电状态被证明出现在死箱图案中存在守恒，并提出了在配体结合时死箱蛋白发生的结构变化，以促进死箱谷胱甘肽的催化作用，改变了死箱基序静电。。

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《International Conference on Bioinformatics and Computational Biology》|2008年||共5页
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作者
Christopher M. Frenz;
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中图分类 TP3-53;
关键词
Structural Biology; Protein Evolution; Enzymes;

机译：结构生物学;蛋白质进化;酶;

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专利

1. Divergent roles of the DEAD-box protein BS-PL10, the urochordate homologue of human DDX3 and DDX3Y proteins, in colony astogeny and ontogeny. [J] . Rosner A, Paz G, Rinkevich B Developmental dynamics: an official publication of the American Association of Anatomists . 2006,第6期

机译：DEAD-box蛋白BS-PL10是人DDX3和DDX3Y蛋白的urochordate同源物，在菌落的形成和个体发育中具有不同的作用。
2. Roles of DEAD-box proteins in RNA and RNP folding [J] . Cynthia Pan, Rick Russell RNA biology . 2010,第6期

机译：DEAD-box蛋白在RNA和RNP折叠中的作用
3. Spliceosome assembly: The unwinding role of DEAD-box proteins [J] . Hamm J., Lamond AI. Current Biology: CB . 1998,第15期

机译：剪接体组装：DEAD-box蛋白的放松作用
4. The Role of Protein Electrostatics in Facilitating the Catalysis of DEAD-box Proteins [C] . Christopher M. Frenz International Conference on Bioinformatics and Computational Biology . 2008

机译：蛋白质静电方法在促进死箱蛋白催化的作用
5. Development of Chemical Tools Targeting DEAD-box Proteins [D] . Barkovich, Krister Jernstedt 2018

机译：针对DEAD-box蛋白的化学工具的开发
6. Glutamate 338 is an electrostatic facilitator of C–Co bond breakage in a dynamic/electrostatic model of catalysis by ornithine aminomutase [O] . Binuraj R K Menon, Navya Menon, Karl Fisher, -1

机译：谷氨酸338是鸟氨酸氨基变位酶催化动力学/静电模型中C-Co键断裂的静电促进剂
7. Bacterial osmosensing: roles of membrane structure and electrostatics in lipid-protein and protein-protein interactions:roles of membrane structure and electrostatics in lipid–protein and protein–protein interactions [O] . Poolman B., Spitzer J.J., Wood J.A., 2004

机译：细菌渗透：膜结构和静电在脂质-蛋白质和蛋白质-蛋白质相互作用中的作用：膜结构和静电在脂质-蛋白质和蛋白质-蛋白质相互作用中的作用

The Role of Protein Electrostatics in Facilitating the Catalysis of DEAD-box Proteins

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