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Development of Microemulsion Containing Prednisolone

机译：含有泼尼松龙微乳液的研制

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Prednisolone, an anti-inflammatory drug with a very slight solubility (0.23 mg/mL at 25 ° C), high permeability and short biological half-life (2-4 h) in oral administration was selected as the candidate drug for sustained drug release. The aim of this research is to formulate and evaluate the stable formation of oil-in-water microemulsion for enhancing the solubility of the model drug. Microemulsion containing oleic acid as oil component, Tween 20 and P188 as main surfactant and co-surfactant at different ratios were evaluated. The microemulsion was characterized by stability test, particle size, clarity, conductivity and pH value. A stable system at nano size (11.6 and 12.3 nm) which possibly enhanced drug solubility with no drug aggregation.
机译：泼尼松，选择具有非常轻微的溶解度（25℃的0.23mg / ml）的抗炎药，口服给药中的高渗透性和短生物半衰期（2-4小时）作为持续药物释放的候选药物。该研究的目的是制定和评估稳定地形成油包水微乳液，以提高模型药物的溶解度。评价含有油酸作为油组分，吐温20和P188作为主要表面活性剂和不同比例的共表面活性剂的微乳液。微乳液的特征在于稳定性试验，粒度，透明度，导电性和pH值。纳米尺寸（11.6和12.3nm）的稳定系统，其可能增强药物溶解度，没有药物聚集。

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