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首页> 外文会议>Mediterranean Conference on Medical and Biological Engineering and Computing >Comparison of Different Radiotherapy Techniques for Locally Advanced Pancreatic Tumors
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Comparison of Different Radiotherapy Techniques for Locally Advanced Pancreatic Tumors

机译：不同放射治疗技术对局部晚期胰腺肿瘤的比较

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Radiotherapy (RT) associated with systemic therapy is the standard treatment for Locally Advanced Pancreatic Cancer (LAPC). The aim of this study was to compare the efficacy of different RT techniques using the clinical data reported in the literature. Clinical data was collected from scientific papers searched in the databases PubMed and ScienceDirect. Thirty-four documents published between 1997 and 2015 were found and met the inclusion criteria: locally advanced adenocarcinoma, unresectable and no metastasis. Values of Complete Response (CR), Partial Response (PR), Stable Disease (SD), Progression Disease, Progression Free Survival (PFS), and Overall Survival (OS) for Three-Dimensional Conformal Radiation Therapy (3DCRT), Intensity Modulated Radiation Therapy (IMRT) and Stereotactic Body Radiotherapy (SBRT) in the treatment of LAPC were collected. For all RT techniques, Response Rate (RR), defined as the sum of CR and PR, was for 3DCRT 25.2% ± 9.5 [range: 5.0%-49.0%], for IMRT 33.5% ± 10.5 [range: 10.6%-55.6%] and for SBRT 52.2% ± 17.7 [range: 13.3%-69.5%J. For all studied techniques, Local Control (LC), defined as the sum of RR and SD, ranged from 47% to 100%; PFS ranged from 4 to 12 months and OS ranged from 6 to 20 months. A significant improvement in overall response rate was obtained with SBRT compared to 3DRCT and IMRT. However, LC, PFS and OS were similar among the three RT techniques.
机译：与全身治疗相关的放射治疗（RT）是局部晚期胰腺癌（LAPC）的标准治疗。本研究的目的是比较使用在文献中报道的临床数据不同RT技术的功效。从科学论文检索的数据库PubMed和ScienceDirect收集临床资料。 1997年至2015年间出版的三十四个文件被发现，并符合纳入标准：局部晚期腺癌，不能切除和无转移。完全缓解（CR），部分缓解（PR），病情稳定（SD），疾病进展，无进展生存期（PFS）和总生存期（OS），三维适形放射治疗（3DCRT），调强放射值疗法（IMRT）和立体定向放射治疗身体（SBRT）LAPC中的治疗收集。对于所有的RT技术，响应率（RR），其定义为CR和PR的总和，是为3DCRT 25.2％±9.5 [范围：5.0％-49.0％]，对于IMRT 33.5％±10.5 [范围：10.6％-55.6 ％]和用于SBRT 52.2％±17.7范围：13.3％-69.5％学家对所有研究的技术中，本地控制（LC），其定义为RR和SD的总和，从47％至100％; PFS的4至12个月〜和OS从6至20个月。用SBRT获得相比3DRCT和IMRT在总反应率甲显著改善。然而，LC，PFS和OS是三个RT技术相似。

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