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A Bioelectric Model of pH in Wound Healing

机译:伤口愈合pH的生物电模型

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摘要

pH has been suggested as a biomarker able to provide reliable information about wound healing. However, the underlying electrophysiological mechanisms responsible for pH changes observed in practice still remain unknown and a lack of bioelectric models capable of simulating these still exists. In this work, the authors have proposed a 2D rectangular wound model based on Nernst-Planck equations for the major ionic species involved in wound healing together with the implication of endogenous electric fields. In order to demonstrate the applicability of the model, both pH and electric potential results have been successfully compared with experimental data in the literature.
机译:已经提出pH作为生物标志物,能够提供有关伤口愈合的可靠信息。然而,负责在实践中观察到的pH变化的潜在的电生理机制仍然是未知的,并且仍然存在缺乏能够模拟这些的生物电模型。在这项工作中,作者提出了一种基于NERNST-PLANCK方程的2D矩形伤口模型,该方程对于伤口愈合的主要离子物种以及内源性电场的含义。为了证明模型的适用性,与文献中的实验数据相比,PH和电势结果均已成功。

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