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首页> 外文会议>Asian BioCeramicSymposium >Characterization of Granular Calcium Sulfate Dihydrate-Gelatin Composite for Bone Void Filler
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Characterization of Granular Calcium Sulfate Dihydrate-Gelatin Composite for Bone Void Filler

机译：骨空隙填料粒状硫酸钙二水合物 - 明胶复合材料的表征

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Calcium sulfate dihydrate (CSD) cement has been used as bone filler for decades. It is also used as antibiotics carrier to treat osteomyelitis. However, CSD cement itself when applied at bone defect has some limitation such as its brittleness. The brittleness limits its handling property. Thus, the aim of this study is to fabricate granular CSD cement-gelatin (CSD-Gel) that has good handling property to be used as bone void filler. To prepare CSD-Gel composite, granular CSD was prepared from calcium sulfate hemihydrate (CaSO_4.0.5H_2O; CSH) and distilled water with water/powder (W/P) ratio of 0.5. The CSD cement was crushed and sieved into 300-500 ?m. The obtained granular CSD was then mixed with 3 wt.% and 7 wt.% gelatin solution, followed by freeze drying for 48 hours. The CSD granules were surrounded by gelatin matrix in all specimens. It was observed that more gelatin matrix found in the space between the granules in in the composite with 7 wt% gelatin compared with that in 3 wt% gelatin. Mechanical evaluation revealed that CSD-Gel 7% has significant higher compressive strength compared to CSD-Gel 3%.
机译：几十年来，硫酸钙二水合物（CSD）水泥用作骨填料。它还用作治疗骨髓炎的抗生素载体。然而，在骨缺陷施用时CSD水泥本身具有一些限制，例如其脆性。脆性限制了其处理物业。因此，本研究的目的是制造具有良好的处理性能的粒状CSD水泥 - 明胶（CSD-GEL）以用作骨空隙填料。为了制备CSD-凝胶复合材料，用硫酸钙半水合物（CasO_4.0.5H_2O; CSH）和蒸馏水，水/粉末（W / P）比为0.5。粒状CSD。将CSD水泥粉碎并筛分成300-500μm。然后将得到的粒状CSD与3重量％和7重量％的粒子混合。％明胶溶液，然后冷冻干燥48小时。所有标本中的CSD颗粒被明胶基质包围。观察到它在复合材料中的颗粒中的空间中发现了更多明胶基质，其具有7wt％明胶与3wt％明胶相比。机械评价显示，与CSD-GEL 3％相比，CSD-GEL 7％具有显着较高的抗压强度。

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