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Exposure to cotton dust and endotoxin causes a significant change in monocyte CD14

机译：暴露于棉粉尘和内毒素导致单核细胞CD14的显着变化

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We have studied changes in the mean linear fluorescence of monocyte CD 14, the endotoxin receptor, in a group of 25 cotton workers (mean age 41 years). Workers were placed into one of 4 exposure categories. Monocyte CD14 fluorescence was measured by flow cytometry, on samples taken on Monday morning (CD 14 pre), after 6 hours (CD 14 +6) and after 72 hours (CD14 +72). Workers in the higher exposure categories 3 (between 10-100 EU/m~3) and 4 (between 100400 EU/m~3) showed significantly increased CD14 expression after 6 hours, rising from a mean of 5.58 at baseline to 8.76 at 6 hours (p=0.01) in group 3, the corresponding figures for the highest exposure group being 6.61 and 9.82. All CD14 values returned to near baseline levels when measured after shift on the fourth working day. We propose that CD14 expression on monocytes may be used to monitor workers exposed to endotoxin and may help to determine the mechanism of action of lipopolysaccharide in producing respiratory in health.
机译：我们研究了一组25个棉花工人（平均41岁）中单核细胞CD 14，内毒素受体的平均线性荧光的变化。工人被置于4种曝光类别中的一个。通过流式细胞术测量单核细胞CD14荧光，在周一早晨（CD 14 pre），6小时（CD14 +6）和72小时后（CD14 + 72）后的样品上测量样品。较高曝光类别3（10-100欧欧元/ m〜3）和4（100400 EU / M〜3之间）的工人显示6小时后显着增加CD14表达，从3.58的平均值上升到6.76第3组中的小时（P = 0.01），最高曝光组的相应图是6.61和9.82。在第四个工作日转移后测量时，所有CD14的值返回到附近的基线水平。我们提出了单核细胞上的CD14表达可用于监测暴露于内毒素的工人，并有助于确定脂多糖在产生健康呼吸系统中的作用机制。

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