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Philosophy of hazard assessment of pesticides

机译：农药危害评估哲学

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The regulation of pesticides dates back to laws relating to food additives and contaminants in the years immediately after the second world war. The studies which were required were designed to assess the risk resulting from residues of pesticides in food. Since that time many new risk assessments have been extrapolated from this database: applicators, harvesters, homeowners etc. At the same time, the list of endpoints studied has been continually increased. This has resulted in toxicology data requirements of increasing complexity and expense. Furthermore, while most of the study designs are designed to study the toxicological effects they are not necessarily well adapted to risk assessment. Some of the studies involve inappropriate modes of administration, having been primarily designed to study drugs. In addition the requirement for statistical analysis of all endpoints leads to a confusion between statistical and biological significance. The science of toxicology has developed greatly since these schemes were put in place and new technologies are available which are capable of replacing some of the old methods. It is time to re-evaluate the way we conduct the toxicology assessment to provide better and more efficient safety evaluations.
机译：在第二次世界大战后立即在几年后，农药的规定返回与食品添加剂和污染物有关的法律。所需的研究旨在评估食品中农药残留的风险。从那时起，许多新的风险评估已经从这个数据库推断出来：申请人，收割机，房主等同时，所研究的终点列表已经不断增加。这导致毒理学数据要求增加了复杂性和费用。此外，虽然大多数研究设计旨在研究毒理学影响，但它们不一定适应风险评估。一些研究涉及不当行政方式，主要是旨在研究药物。此外，所有终点对统计分析的要求导致统计和生物学意义之间的混乱。毒理学科学已经发展起来，因为这些方案已经到位，并且可以使用新技术，能够更换一些旧方法。是时候重新评估我们进行毒理学评估，以提供更好更高的安全评估。

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