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Functionalized Porous Networks Obtained from Semi-IPNs: Evaluation in Ion- Exchange Chromatography

机译：从半IPN获得的功能化多孔网络：离子交换色谱中的评估

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Over the past few years, porous polymeric materials have been the subject of widespread interest and intense research as they find a large variety of applications in many areas, including separation and filtration techniques, biomolecule immobilization, controlled drug release, tissue engineering, as well as template-assisted synthesis of nanomaterials. The design of porous polymers generally involves the introduction of various types of porogens (solvents, gases, small or macro-molecules) within polymer structures, followed by their selective removal. Miscellaneous template-oriented routes, including molecular imprinting, supramolecular self-assembly, and selective degradation of block copolymers, have been developed to create polymeric materials with defined porosity. Our group has recently reported a straightforward and effective approach for generating porous networks with controlled morphology. It implies the preparation of semi- Interpenetrating Polymer Networks (semi-IPNs) constituted of oligoester sub-chains entrapped in a poly(methyl methacrylate) (PMMA) sub-network, followed by the extraction of un-cross-linked oligomers. The functionalization of such porous frameworks could provide a great opportunity to broaden their potential applications. Herein, we report on the preparation of functional porous networks derived from poly(ε-caprolactone) (PCL)/poly(methyl methacrylate-co-methacrylic acid) (poly(MMA-co-MAA)) semi-IPNs, and their subsequent evaluation as cation-exchange supports in Ion- Exchange chromatography (IEC). This chromatographic technique is widely used for the separation of ionic and ionisable compounds. Classical ion-exchange techniques have indeed been used for the separation of inorganic cations and anions, amino acids, organic acids, amines, peptides, and proteins. This communication aims at illustrating the retention behavior of model proteins with the COOH- functionalized porous materials engineered by the semi-IPN approach.
机译：在过去的几年里，多孔聚合物材料是广泛兴趣和激烈的研究主题，因为它们在许多领域发现各种各样的应用，包括分离和过滤技术，生物分子固定化，受控药物释放，组织工程以及模板辅助合成纳米材料。多孔聚合物的设计通常涉及在聚合物结构中引入各种类型的孔胶（溶剂，气体，小或宏观分子），然后选择性去除。已经开发出杂种面向模板的途径，包括分子印迹，超分子自组装和嵌段共聚物的选择性降解，以产生具有限定孔隙率的聚合物材料。本集团最近报告了一种具有受控形态的多孔网络的直接和有效的方法。它意味着制备由捕获在聚（甲基丙烯酸甲酯）（PMMA）亚网络中的低偶联亚链组成的半互穿聚合物网络（半IPN），然后提取未交联的低聚物。这种多孔框架的功能化可以提供扩大其潜在应用的绝佳机会。在此，我们报告了衍生自聚（ε-己内酯）（PCL）/聚（甲基丙烯酸甲酯 - 共甲基丙烯酸）（聚（MMA-CO-MAA））半IPN的功能多孔网络的制备及其随后的评估作为离子交换色谱（IEC）中的阳离子交换支持。这种色谱技术广泛用于离子和可离子化合物的分离。确实用于分离无机阳离子和阴离子，氨基酸，有机酸，胺，肽和蛋白质的经典离子交换技术。该通信旨在说明模型蛋白质与通过半IPN方法工程的官能化多孔材料的保留行为。

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