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首页> 外文会议>Society of Photo-Optical Instrumentation Engineers Conference on Nanoparticles and Nanostructured Surfaces >Deleterious Effects of Sunscreen Titanium Dioxide Nanoparticles on DNA. Efforts to Limit DNA Damage by Particle Surface Modification
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Deleterious Effects of Sunscreen Titanium Dioxide Nanoparticles on DNA. Efforts to Limit DNA Damage by Particle Surface Modification

机译：防晒二氧化钛纳米粒子对DNA的有害作用。通过颗粒表面改性来限制DNA损伤的努力

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Sunlight can have deleterious effects on humans: causes sunburns and is the principal cause of skin cancers. Usage of TiO_2 (and ZnO) in sunscreen lotions, widely used as UVA/UVB blockers, and intended to prevent sunburns and "to protect" consumers from skin cancers (carcinomas and melanomas) is examined. Although used to mineralize many undesirable organic pollutants TiO_2 is considered to be a safe physical sunscreen agent because it reflects and scatters both UVB (290-320 nm) and UVA (320-400 nm) sunlight; however, it also absorbs substantial UV radiation which, in aqueous media, yields hydroxyl radical (·OH) species. These species cause substantial damage to DNA {J. Photochem. Photobiol. A:Chem., 111 (1997) 205}. Most importantly sunlight-illuminated sunscreen TiO_2 particles catalyze DNA damage both in vitro and in human cells {FEBS Letters, 418 (1997) 87}. These results raise concerns on the overall effects of sunscreens and raise the question on the suitability of photoactive TiO_2 as a sunscreen component without further studies. The photocatalytically active nature of these metal oxides necessitates some changes since even the TiO_2 specimens currently used in suncreams cause significant DNA strand breaks.
机译：阳光可能对人类有害影响：导致晒伤，是皮肤癌症的主要原因。使用TiO_2（和ZnO）在防晒乳液中，广泛用作UVA / UVB阻滞剂，并旨在防止晒伤和“保护”消费者来自皮肤癌症（癌和黑色素）。虽然用于矿化许多不期望的有机污染物TiO_2被认为是一种安全的物理防晒剂，因为它反映了UVB（290-320nm）和UVA（320-400nm）的阳光;然而，它也吸收大量UV辐射，其在水性介质中产生羟基自由基（·OH）物种。这些物种对DNA {J. photochem。 Photobiol。答：Chem。，111（1997）205}。最重要的是阳光照明防晒剂TiO_2颗粒在体外和人体细胞中催化DNA损伤{FEBS字母，418（1997）87}。这些结果提高了对防晒霜的整体影响的担忧，并提出了关于光活性TiO_2作为防晒组分的适用性的问题，而无需进一步研究。这些金属氧化物的光催化性质需要一些变化，因为即使目前在阳光下使用的TiO_2标本也会导致显着的DNA链断裂。

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