• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>International Symposium on Ganoderma Research >Chemical and Biochemical Basis of the Anti-tumor Properties of Ganoderma lucidum
【24h】

Chemical and Biochemical Basis of the Anti-tumor Properties of Ganoderma lucidum

机译：Ganoderma lucidum抗肿瘤性质的化学和生化基础

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The fruiting bodies of Ganoderma lucidum are edible, medicinal mushrooms known as Ling Zhi in China. Ling Zhi has been used in traditional Chinese medicine (TCM) for over 2000 years with a reputation rivaling that of ginseng. In addition to the fruiting bodies, the spores and cultivated mycelia have recently been used as health foods and herbal medicines. As a superior herbal medicine, it has been used in TCM for promotion of vitality and longevity. In modern Chinese medicine, Ganoderma lucidum is used in the treatment of debility and weakness, hepatitis, diabetes, altitude sickness, cardiovascular diseases, AIDS and cancer. Scientific studies on extracts and substances from Ganoderma lucidum have demonstrated their anti-aging, cardiovascular, hepato-protective, hypoglycemic, immuno-modulatory, anti-viral and anti- tumor effects. This evidence provides a pharmacological basis for their ancient and contemporary medical applications. Chemical investigations on the fruiting bodies, spores and mycelia of Ganoderma lucidum have shown that these mushrooms contain various bioactive substances. Active constituents of Ganoderma lucidum include polysaccharides, proteins, nucleosides, fatty acids, terpenoids and sterols. Water or alcohol extracts have been used for investigation of its biological activities. Water extract contains biological compounds that are responsible for its immunological and anti-inflammatory properties. In contrast, alcohol extract contains biological compounds that lower blood cholesterol levels, blood glucose levels, and platelet aggregation. While the anti-tumor effects can be attributed both to the water soluble polysaccharide and alcohol soluble triterpenes. Recent clinical and pharmacological research substantiating the benefits and effects of Ganoderma lucidum has focused on tumor activities. This presentation .attempts to review and analyze our current knowledge on the anti-tumor properties and mechanism of Ganoderma lucidum extracts. Some terpenoids and their derivatives isolated from Ganoderma lucidum are cytotoxic and have antitumor activities. Over one hundred different triterpenoids have been found in fruiting bodies, spores and mycelia of Ganoderma lucidum. These include highly oxidized lanostanoid-type triterpenes, such as ganoderic acids, ganoderenic acids, ganolucidic acids, lucidenic acids, ganoderiol type 1 and type 2, ganoderals, lucidones, furnaoganoderic acid and other terpenoid components. Some of these compounds are known for their anti-proliferative properties investigated in various cancer cell lines. Recent research has been expanded into their antiangiogenesis and apoptotic properties. The water extracts of Ganderma lucidum were reported to have immuno-modulatory and anti-tumor activities in many animal studies. Different anti-tumor polysaccharides and protein bound polysaccharides including β-D-glucan, glucuronoglucan, xycoglucan, mannoglucan and their protein complexes have been fractionated and purified. The water-soluble anti-tumor substances are ganoderan, GL-A, GL-B, GL-C, GLB-7 and β-immunan. Recently, a fucose-containing glycoprotein fraction with immuno-modulatory and anti-tumor activities has been identified from the water extract of Ganoderma lucidum. Functional and proteomics analyses indicate that a fucose-containing polysaccharide fraction is responsible for stimulating the expression of tumoricide cytokines. Mechanistic studies on the anti-tumor activities of β-D-glucan and GL-B have indicated their anti-tumor activities to be accomplished by enhancing host mediated mechanisms including increased IL-2 production and stimulation of cytotoxic T lymphocytes and NK activity. The hypothesis that some of the active constituents of Ganoderma lucidum may be able to skew the immune system away from the Th2 state into the Th1 state to benefit the tumor-bearing host will be discussed.
机译：灵芝的子实体被称为灵芝在中国的食用，药用蘑菇。菱智已经在中国传统医药（TCM）被用于超过2000年的声誉足以媲美人参。除了子实体，孢子和菌丝体种植近来被用作保健食品和中药材。作为一个卓越的草药，它已被中医用于市场推广的活力和长寿。在中国现代中药，灵芝是虚弱和无力，肝炎，糖尿病，高原病，心血管疾病，艾滋病和癌症的治疗。从灵芝提取物和物质科学研究已证实了他们的抗老化，心血管，肝保护，降血糖，免疫调节，抗病毒和抗肿瘤作用。这方面的证据提供了自己的古老和现代医疗应用的药理学基础。在子实体，孢子和灵芝菌丝体化学的研究表明，这些香菇中含有多种生物活性物质。灵芝的有效成分包括多糖，蛋白质，核苷，脂肪酸，萜类化合物和甾醇。水或醇提取物已被用于其生物活性的调查。水提取物含有，它们负责其免疫学和抗炎特性的生物化合物。与此相反，醇提取物中含有的生物化合物的是降低血液中胆固醇水平，血糖水平，和血小板聚集。而抗肿瘤效果可以两归因于水溶性多糖和醇溶性三萜类化合物。最近的临床和药理研究充实的好处和灵芝的影响一直专注于肿瘤活性。此演示文稿.attempts审查和分析对灵芝提取物的抗肿瘤特性和机理我们现有的知识。从灵芝中分离一些萜类化合物及其衍生物具有细胞毒性，并具有抗肿瘤活性。超过一百个不同的三萜类化合物已在子实体，孢子和灵芝菌丝体被发现。这些包括高氧化lanostanoid型三萜类化合物，如灵芝酸，ganoderenic酸，ganolucidic酸，赤芝酸，ganoderiol 1型和2型，ganoderals，lucidones，furnaoganoderic酸和其它萜类化合物组分，例如。这些化合物中有些是已知的在各种癌细胞系研究了它们的抗增殖特性。最近的研究已经扩展到他们的抗血管生成和细胞凋亡特性。灵芝的水提取物据报道，在许多动物研究免疫调节和抗肿瘤活性。不同的抗肿瘤多糖和蛋白结合多糖，包括β-d葡聚糖，glucuronoglucan，xycoglucan，甘露葡聚糖和它们的蛋白质复合物已被分馏和纯化。水溶性的抗肿瘤物质是灵芝多糖，GL-A，GLB，GL-C，GLB-7和β-immunan。近来，随着免疫调节和抗肿瘤活性的含岩藻糖蛋白部分已经被识别从灵芝的水提取物。功能和蛋白质组学分析表明，含岩藻糖的多糖级分是负责刺激tumoricide细胞因子的表达。上的β-d葡聚糖和GL-B的抗肿瘤活性机理的研究已经表明，以通过增强宿主介导的机制，包括增加的IL-2产生和细胞毒性T淋巴细胞和NK细胞活性的刺激来完成它们的抗肿瘤活性。一些灵芝的活性成分可以是能够歪斜免疫系统从Th2的状态消失在Th1细胞状态向荷瘤宿主受益假设将被讨论。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号