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首页> 外文会议>AIChE Annual Meeting >Spray Drying of Uniform Silica Microencapsulates: Implications for Controlled Release
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Spray Drying of Uniform Silica Microencapsulates: Implications for Controlled Release

机译：喷雾干燥均匀二氧化硅微胶囊：对控释的影响

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Spray drying is a scalable route for particle formation with easy product recovery. Conventional spray drying produces broad distributions of particles with various morphologies in a single batch, due to non-uniform distribution of droplets / spray trajectories and different residence times [1]. This renders any interpretation of particle behaviour in relation to their physico-chemical properties virtually impossible. Here, uniform silica microparticles encapsulating vitamin B_(12), which was homogenously distributed within each particle, were synthesised in a single step via a micro-fluidic-jet-spray-dryer (Figure 1). The dryer utilised a micro-fluidic-aerosol-nozzle for continuous generation of monodisperse droplets from complex precursors [2]. The uniformity of the particles allowed direct correlations between their properties and the release behaviour of vitamin B_(12) to be investigated, without the complications of wide size distribution or non-uniform shapes. The effects of additives in the forms of lactose and Na-alginate to the properties of these microparticles were demonstrated. Spherical particles with relatively smooth surface were obtained with lactose addition, while incorporation of Na-alginate resulted in noticeably increasing surface roughness with higher amount added (Figure 2). Lactose addition also accelerated the release of the encapsulated vitamin B_(12), due to the relatively fast lactose dissolution that allowed buffer to penetrate into the matrix to facilitate diffusion and silica erosion. On the contrary, Na-alginate slowed down the release considerably by serving as an additional barrier to decelerate silica matrix erosion. Release kinetics data indicated diffusion as the main release mechanism independent of the additives. The release profiles from different compositions of the synthesized particles demonstrated good agreement with computational results, highlighting the reproducibility of particles produced with this technique and the ability to modulate the release behaviour directly from the precursor compositions [3].
机译：喷雾干燥是一种可伸缩的颗粒形成途径，具有易于产物回收。由于液滴/喷涂轨迹的不均匀分布和不同的停留时间[1]，常规喷雾干燥产生具有各种形态的颗粒的广泛分布。这使得与其物理化学物质相关的任何对粒子行为的解释几乎不可能。这里，通过微流体 - 喷射干燥器在单一步骤中合成均匀的二氧化硅微粒包封在每个颗粒内的维生素B_（12）包封在每种颗粒内的维生素B_（12）进行合成（图1）。干燥器利用微流体 - 气溶胶喷嘴，用于从复合前体的连续产生单分散液滴[2]。颗粒的均匀性允许研究其性质与维生素B_（12）的释放行为之间的直接相关性，而无需宽尺寸分布的并发症或不均匀的形状。对乳糖和Na-藻酸盐形式的添加剂对这些微粒的性质的影响。用乳糖加入获得具有相对光滑的表面的球形颗粒，同时掺入Na-藻酸盐，产生明显增加的表面粗糙度，加入较高的量（图2）。乳糖添加也加速了包封的维生素B_（12）的释放，由于相对快的乳糖溶解，使缓冲液渗透到基质中以促进扩散和二氧化硅腐蚀。相反，通过用作减速二氧化硅基质侵蚀的额外屏障，纳藻酸盐放缓了释放。释放动力学数据表明扩散作为与添加剂无关的主要释放机制。来自合成颗粒的不同组合物的释放曲线与计算结果表现出良好的一致性，突出了用该技术产生的颗粒的再现性，并直接从前体组合物调节释放行为的能力[3]。

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