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NMR Study of Poly(γ-Glutamic Acid) and Partially Benzylated Poly (γ-Glutamic Acid): Nanoparticles in Solution

机译：聚（γ-谷氨酸）和部分苄基化聚（γ-谷氨酸）的NMR研究：溶液中的纳米粒子

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Poly(γ-glutamic acid) (γ-PGA) and its partially benzylami-dated (hydrophobized) derivatives were prepared and studied in solution by means of dynamic light scattering (DLS), ID, 2D and PGSE NMR in order to determine the structure, size and aggregation in solution. By pH potentiometric titrations in aqueous solution the apparent pK ≈ 4 of γ-PGA was determined. The measured diffusion coefficients as a function of pH showed the swelling of γ-PGA by deprotonation of carboxyls. DLS measurements showed a certain degree of aggregation even in dilute solution. The degree of aggregation is increased in the presence H_2PO_4-and HPO_4~(2-) buffer anions. Benzylamidation of 30-50% of caboxylates resulted in folded structure of the BzPGA, probably spherical like nanoparticles, verified by NMR diffusiometry and 2D NOE spectroscopy.

机译：通过动态光散射（DLS），ID，2D和PGSE NMR制备聚（γ-谷氨酸）（γ-PGA）及其部分苄基致氧化（疏水化）衍生物，并在溶液中研究，以确定结构解决方案中的大小和聚合。通过pH水溶液中的pH电位滴定，测定表观pk≈4的γ-pga。测量的扩散系数作为pH的函数，通过羧基的去质子显示γ-PGA的溶胀。即使在稀释溶液中，DLS测量也表现出一定程度的聚集。在存在H_2PO_4和HPO_4〜（2-）缓冲阴离子中，聚集程度增加。苄基酰胺化30-50％的Caboxyly导致BZPGA的折叠结构，可能是球形的纳米颗粒，通过NMR扩散测定法和2D NOE光谱验证。

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《Conference on Colloid Chemistry》|2008年||共9页
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作者
Z. Nagy; L. Novak; C. Kozma; M. Berka; I. Banyai;
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正文语种
中图分类胶体化学（分散体系的物理化学）;
关键词
aggregation; amphipatic polymers; nmr diffusiometry; poly(γ-glutamic acid); self-assembly;

机译：聚集;两性聚合物;NMR扩散测定法;聚（γ-谷氨酸）;自组装;

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1. Chemical synthesis of poly-gamma-glutamic acid by polycondensation of gamma-glutamic acid dimer: Synthesis and reaction of poly-gamma-glutamic acid methyl ester [J] . Sanda F., Endo T., Fujiyama T. Journal of Polymer Science, Part A. Polymer Chemistry . 2001,第5期

机译：γ-谷氨酸二聚体缩聚化学合成聚γ-谷氨酸：聚γ-谷氨酸甲酯的合成与反应
2. Chemical Synthesis of Poly-#gamma#-glutamic Acid by Polycondensation of #gamma#-Glutamic Acid Dimer: Synthesis and Reaction of Poly-#gamma#-glutamic Acid Methyl Ester [J] . FUMIO SANDA, TAIZO FUJIYAMA, TAKESHI ENDO Journal of Polymer Science, Part A. Polymer Chemistry . 2001,第5期

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3. Polymeric Calcium Phosphate Cements Incorporated with Poly-gamma-Glutamic Acid: Comparative Study of Poly-gamma-Glutamic Acid and Citric Acid [J] . Kim SS, Seo M, Chung JW, Journal of Applied Polymer Science . 2009,第2期

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4. NMR Study of Poly(γ-Glutamic Acid) and Partially Benzylated Poly (γ-Glutamic Acid): Nanoparticles in Solution [C] . Z. Nagy, L. Novak, C. Kozma, Conference on Colloid Chemistry . 2008

机译：聚（γ-谷氨酸）和部分苄基化聚（γ-谷氨酸）的NMR研究：溶液中的纳米粒子
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6. Genetic control of major histocompatibility complex-linked immune responses to synthetic polypeptides in man: poly(L-phenylalanine L-glutamic acid)-poly (DL-alanine)--poly(L-lysine) and L-glutamic acid L-alanine L-tyrosine (60:30:10). [O] . M M Chan, W B Bias, S H Hsu, 1984

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7. Dielectric analysis of aqueous poly(l-glutamic acid) and poly-l-(glutamic acid4, Tyrosine1) solutions at high frequencies from capacitance measurements [O] . Monreal Jorge, Eggers Tatiana, Phan Manh-Huong 2016

机译：从电容测量中高频分析聚（1-谷氨酸）水溶液和聚-1-（谷氨酸4，酪氨酸1）溶液
8. Magnetic Resonance Study of the Segmental Motion and Local Conformations of Poly-(L-Glutamic Acid) in Aqueous Solutions [R] . Tsutsumi, A., Perly, B., Forchioni, A., 1978

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NMR Study of Poly(γ-Glutamic Acid) and Partially Benzylated Poly (γ-Glutamic Acid): Nanoparticles in Solution

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