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首页> 外文期刊>Journal of Polymer Science, Part A. Polymer Chemistry >Chemical Synthesis of Poly-#gamma#-glutamic Acid by Polycondensation of #gamma#-Glutamic Acid Dimer: Synthesis and Reaction of Poly-#gamma#-glutamic Acid Methyl Ester
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Chemical Synthesis of Poly-#gamma#-glutamic Acid by Polycondensation of #gamma#-Glutamic Acid Dimer: Synthesis and Reaction of Poly-#gamma#-glutamic Acid Methyl Ester

机译：通过＃γ-谷氨酸二聚体的缩聚反应化学合成聚γ-谷氨酸：聚γ-谷氨酸甲酯的合成与反应

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摘要

#alpha#-Methyl glutamic acid (L-L)-, (L-D)-, (D-L)-, and (D-D)-1-dimers were synthe- sized from L- and D-glutamic acids, and the obtained dimmers were subjected to polycon- densation with 1-(3-dimethylaminopropyl)-3-ethylcarbodiirnide hydrochloride and 1-hydroxybenzotriazole hydrate as condensation reagents. Poly-1-glutamic acid ( 1- PGA) methyl ester with the number-average molecular weights of 5000-20,000 were obtained by polycondensation in N,N-dimethylformamide in 44-91% yields. The poly- condensation of (L-L)- and (D-D)-dimers afforded the polymers with much larger l[aJ.D3O1 compared with the corresponding dimmers. The polymer could be transformed into 1-PGA by alkaline hydrolysis or transesterification into a-benzyl ester followed by hydrogenation.
机译：由L-和D-谷氨酸合成＃alpha＃-谷氨酸甲酯（LL）-，（LD）-，（DL）-和（DD）-1-二聚体，并将得到的二聚体进行用1-（3-二甲基氨基丙基）-3-乙基碳二亚胺盐酸盐和1-羟基苯并三唑水合物作为缩合剂进行缩聚反应。通过在N，N-二甲基甲酰胺中缩聚得到数均分子量为5000-20,000的聚-1-谷氨酸（1-PGA）甲酯，产率为44-91％。与相应的二聚体相比，（L-L）-和（D-D）-二聚体的聚缩合为聚合物提供了更大的l [aJ.D3O1]。该聚合物可通过碱水解或酯交换成α-苄基酯然后氢化而转化为1-PGA。

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