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首页> 外文会议>International Conference of the European Aquaculture Society >EFFECTS OF METHISOPRINOL ON THE NONSPECIFIC CELLULAR AND HUMORAL IMMUNE SYSTEM IN INTENSIVE REARING OF EUROPEAN EEL (ANGUILLA ANGUILLA)
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EFFECTS OF METHISOPRINOL ON THE NONSPECIFIC CELLULAR AND HUMORAL IMMUNE SYSTEM IN INTENSIVE REARING OF EUROPEAN EEL (ANGUILLA ANGUILLA)

机译：甲烷醇对欧洲鳗鱼密集饲养的非特异性细胞和体液免疫系统的影响（Anguilla Anguilla）

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The European eel is a one of the most important fish species cultured in European countries. This species is euryhaline fish and have complicated life cycle. The intensive rearing of European eels and Japanese eels are systematically developing in many countries. Successful commercial production of eel species has been facilitated by the intensification of larval and fingerling rearing techniques. With develop of intensive rearing the new infectious diseases are developing in European eel. The immunesystem is a highly evolved system that functions to provide organisms with the ability to resist pathogenic agents and characterised by two pathways: innate and acquired immunity. The nonspecific defence mechanisms in fish consists of a large number ofhumoral and cellular factors which play an important role as the first line of defence against a wide range of infective agents. The immune system can be exposed to a variety of physical and chemical stressors. The interactions of xenobiotics with the immune system could finally induced immunosuppression with develop of viral, bacterial or fungal diseases. It is of great importance to study the early detection of immune deficiencies and modulation of the nonspecific defence mechanisms and protection against diseases. Methisoprinol is a synthetic compound and presents low toxicity and has been shown act in vitro and in vivo by inhibiting the replication of various viruses in fish (Siwicki et al. 2002). It exerts antiviral activity and immunomodulating influence on cell- mediated immunity and protection against viral diseases in fish were observed (Siwicki et al. 2003). The aim of present study was to determine the influence of methisoprinol on the nonspecific cellular and humoral defence mechanisms inintensive rearing of European eel.
机译：欧洲鳗鱼是在欧洲国家培养的最重要的鱼类之一。这种物种是euryhaline鱼并具有复杂的生命周期。欧洲鳗鱼和日本鳗的密集饲养系统地在许多国家系统地发展。通过幼虫和鱼种饲养技术的强化，已经促进了欧利物种的成功商业生产。随着强化饲养，新型传染病正在欧洲鳗鱼发展。免疫系统是一种高度发展的系统，可以提供具有抵抗致病药物的能力并以两种途径为特征的能力提供生物：先天性和获得的免疫力。鱼类中的非特异性防御​​机制包括大量的高度和蜂窝因素，这些因素在于对广泛的感染剂的第一道防线发挥着重要作用。免疫系统可以暴露于各种物理和化学压力源。异恶霉菌与免疫系统的相互作用最终能够通过发展的病毒，细菌或真菌疾病诱导免疫抑制。研究早期发现免疫缺陷和对非特异性的防御机制和保护免受疾病的调查是非常重要的。甲基戊丙醇是一种合成化合物，并呈低毒性，并通过抑制鱼类中各种病毒的复制（Siwicki等，2002）的复制，在体外和体内显示出毒性。它施加抗病毒活性和免疫调节对细胞介导的免疫力和对鱼类病毒疾病的影响（Siwicki等，2003）。目前研究的目的是确定甲基戊醇对欧洲鳗鱼的非特异性细胞和体液防御机制的影响。

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