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THE USE OF A NOVEL CASA SYSTEM, BASED ON OPEN SOURCE SOFTWARE, FOR THE ANALYSIS OF SPERM MOTILITY PARAMETERS

机译:基于开源软件的新型CASA系统的使用,用于分析精子运动参数

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The effect of DDT and its metabolites on sperm motility parameters of two fresh water fish species (Clarias gariepinus and Oreochromis mossambicus) from two exposed and one reference site in the Limpopo Province, South Africa, were studied using a novel computer assisted sperm analysis (CASA) system based on open source software (Wilson-Leedy & Ingermann, 2007). This software was developed and adapted to suit the test species, for characterization of sperm motility parameters. It has been suggested that the cause of declining male reproductive health is related to synthetic substances that bioaccumulate and act as hormonally active substances, such as organochlorines (Skakkebaek & Keiding, 1994; Dalvie et al, 2004). A pesticide DDT and its metabolites are known endocrine disrupting chemicals that have estrogenic and anti-androgenic properties. They have detrimental effects on growth and reproduction (Kavlock et al., 1996; Sonnenschein & Soto, 1998). Although DDT was banned internationally, it is still used for Malaria vector control in areas of South Africa in accordance with the Stockholm convention (Bouwman, 2004).
机译:DDT及其代谢物对南非林普省林帕省的两个淡水鱼类(Clarias Gariepinus和Oreoochromis Mossambicus)的精子运动参数的影响,使用了一种新颖的计算机辅助精液分析(Casa )基于开源软件的系统(Wilson Leedy&Ingermann,2007)。该软件开发并适合适合测试物种,以表征精子运动参数。有人建议,雄性生殖健康衰退的原因与生物累计和充当嗅觉活性物质(如有机氯(Skakkebaek&Keiding)的合成物质有关,例如有机氯(Skakkebaek,1994; Dalvie等,2004)。农药DDT及其代谢物是已知的内分泌破坏具有雌激素和抗雄激素性质的化学物质。它们对生长和繁殖有不利影响(Kavlock等,1996; Sonnenschein&Soto,1998)。虽然DDT是在国际上被禁止的,但仍然根据斯德哥尔摩大会(Bouwman,2004)的南非地区疟疾矢量控制。

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