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首页> 外文会议>China International Conference on High-Performance Ceramics >Exploring the Osteoinductivity of Calcium Phosphate Ceramics/PLA or Collagen Composites
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Exploring the Osteoinductivity of Calcium Phosphate Ceramics/PLA or Collagen Composites

机译：探索磷酸钙陶瓷/ PLA或胶原复合材料的骨诱导性

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The purpose of this study is to explore the osteoinductivity of the composite materials (calcium phosphate ceramics/PLA or collagen composites) with similar physical character of osteoinductive calcium phosphate ceramics and the influence of the chemical composition of the composite materials on osteoinductivity, and also to provide an experimental evidence for optimizing the design of the composite materials. Two kinds of composite materials were prepared. One (BCP/PLA) is fabricated with different ratio of BCP (biphasic calcium phosphate) ceramics powder and PDLLA powder through the particulate-leaching technique. The other (BCP/collagen) is that BCP ceramics sintered at 1250°C and modified with collagen. The porous materials cylinders with Φ 5×8 mm were prepared. SEM was used to observe the microstructure and physical morphology of the composite materials. The two groups of composite materials cylinders were implanted in the dorsal muscles of four dogs. Six samples of each group were implanted in each dog respectively. The specimens were harvested at 2, 4, 12 and 24 weeks post operation, and thin decalcified sections were prepared for light microscopy (LM) analysis to evaluate their osteoinductivity and compare the capability of osteoinduction. The fibro-tissue and bone-like tissue were observed in the two composites, but no obvious bone formation was found in the tested periods. The results indicated that the composite materials could modify the mechanical property of ceramics. However, if the composite materials were biodegraded soon, new bone could not form into the scaffold, and the calcium phosphate should be the major component of osteoinductive materials.
机译：本研究的目的是探讨复合材料（磷酸钙陶瓷/ PLA或胶原复合材料）的骨诱导性，其具有骨诱导磷酸钙陶瓷的相似性物理性质及复合材料的化学成分对骨液诱导性的影响，以及提供优化复合材料设计的实验证据。制备两种复合材料。一种（BCP / PLA）通过颗粒浸出技术具有不同比例的BCP（双相磷酸钙）陶瓷粉和PDLLA粉末的比例制造。另一种（BCP /胶原蛋白）是BCP陶瓷在1250℃下烧结并用胶原蛋白改性。制备具有Φ5×8mm的多孔材料圆柱体。 SEM用于观察复合材料的微观结构和物理形态。两组复合材料圆柱体植入四只狗的背部肌肉中。每组六个样品分别植入每只狗。在操作后2,4,12和24周收获标本，并制备光学显微镜（LM）分析的薄折叠部分，以评估其骨诱导性并比较骨诱导的能力。在两种复合材料中观察到纤维组织和骨状组织，但在测试时期没有发现明显的骨形成。结果表明，复合材料可以改变陶瓷的力学性能。但是，如果很快就生物降解了复合材料，则新骨不能形成支架，磷酸钙应该是骨诱导材料的主要成分。

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