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State Key Laboratory of Precision Measuring Technology and Instruments, College of Precision Instruments Opto-electronics Engineering, Tianjin University, Tianjing, 300072, People's Republic of China

机译：天津大学精密仪器与光电电子工程学院精密测量技术与仪器的国家重点实验室，天井，中华民国300072

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Weak signal and great background variation have been the major challenges for noninvasive measurement of blood glucose. Two kinds of noise are analyzed, and it is found out that, when instruments achieve a high level of signal to noise ratio, physiological variation other than glucose concentration becomes the dominant over instrument noise. After analyzing the sensitivity of glucose concentration on diffuse reflectance spectroscopy at different source-detector separation, floating-reference method is proposed firstly. This method discusses how to extract signal relating to glucose and signal only relating to background variation respectively, by making use of two special points, reference point and measuring point. Experiments on phantom and Monte Carlo simulations have been performed to validate the feasibility of floating-reference method.

机译：信号弱信号和大背景变化是血糖非侵入性测量的主要挑战。分析了两种噪声，发现，当仪器实现高电平的信噪比时，除葡萄糖浓度之外的生理变化将成为仪器噪声的主导。在分析在不同源检测器分离时衍射反射光谱对漫射反射光谱的敏感性之后，首先提出浮选参考方法。该方法讨论如何通过利用两个特殊点，参考点和测量点提取与葡萄糖和信号有关的信号。已经进行了对幻影和蒙特卡罗模拟的实验，以验证浮选方法的可行性。

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来源
《Conference on Optical Diagnostics and Sensing》|2005年||共8页
会议地点
作者
Yunhan Luo; Lin An; Zhen Ma; Rong Liu; Kexin Xu;
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原文格式 PDF
正文语种
中图分类光、激光生物医学;
关键词
NIR Spectroscopy; Noninvasive Measurement; Blood Glucose; Floating-reference Method;

机译：NIR光谱;非侵入性测量;血糖;浮选参考方法;

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State Key Laboratory of Precision Measuring Technology and Instruments, College of Precision Instruments Opto-electronics Engineering, Tianjin University, Tianjing, 300072, People's Republic of China

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